The silent threat: asymptomatic parasitemia and malaria transmission

Scale-up of malaria control interventions has resulted in a substantial decline in global malaria morbidity and mortality. Despite this achievement, there is evidence that current interventions alone will not lead to malaria elimination in most malaria-endemic areas and additional strategies need to...

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Bibliographic Details
Published in:Expert review of anti-infective therapy Vol. 11; no. 6; pp. 623 - 639
Main Authors: Lindblade, Kim A, Steinhardt, Laura, Samuels, Aaron, Kachur, S Patrick, Slutsker, Laurence
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.06.2013
Expert Reviews Ltd
Informa Healthcare
Subjects:
Adolescent
Adult
Aged
Animals
Anopheles - parasitology
antimalarial
asymptomatic
Asymptomatic Infections
Child
Child, Preschool
Disease transmission
Disease Vectors
Distribution
elimination
Humans
Infant
Infant, Newborn
infection
interventions
Malaria
Malaria, Falciparum - diagnosis
Malaria, Falciparum - immunology
Malaria, Falciparum - parasitology
Malaria, Falciparum - transmission
Medical research
Medicine, Experimental
Middle Aged
parasite
Parasitemia - diagnosis
Parasitemia - immunology
Parasitemia - parasitology
Parasitemia - transmission
Plasmodium falciparum - physiology
ISSN:1478-7210, 1744-8336, 1744-8336
Online Access:Get full text
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Summary:Scale-up of malaria control interventions has resulted in a substantial decline in global malaria morbidity and mortality. Despite this achievement, there is evidence that current interventions alone will not lead to malaria elimination in most malaria-endemic areas and additional strategies need to be considered. Use of antimalarial drugs to target the reservoir of malaria infection is an option to reduce the transmission of malaria between humans and mosquito vectors. However, a large proportion of human malaria infections are asymptomatic, requiring treatment that is not triggered by care-seeking for clinical illness. This article reviews the evidence that asymptomatic malaria infection plays an important role in malaria transmission and that interventions to target this parasite reservoir may be needed to achieve malaria elimination in both low- and high-transmission areas.
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ISSN:1478-7210
1744-8336
1744-8336
DOI:10.1586/eri.13.45