Evaluating the Potential Association Between Lipoprotein(a) and Atherosclerosis (from the Mediators of Atherosclerosis Among South Asians Living in America Cohort)

We sought to report the distribution of Lp(a) levels in the Mediators of Atherosclerosis among South Asians Living in America cohort of participants who were free from clinical atherosclerotic cardiovascular disease (ASCVD) at baseline and to evaluate the cross-sectional association with atheroscler...

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Vydané v:The American journal of cardiology Ročník 123; číslo 6; s. 919 - 921
Hlavní autori: Huffman, Mark D., Kandula, Namratha R., Baldridge, Abigail S., Tsai, Michael Y., Prabhakaran, Dorairaj, Kanaya, Alka M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 15.03.2019
Elsevier Limited
Predmet:
Adult
Aged
Aged, 80 and over
Arteriosclerosis
Asia, Southeastern - ethnology
Asian Americans
Asian Continental Ancestry Group
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - diagnosis
Atherosclerosis - ethnology
Biomarkers - blood
Black people
Blood pressure
Calcification
Calcification (ectopic)
Cardiovascular disease
Cardiovascular diseases
Carotid Intima-Media Thickness
Cholesterol
Coronary Angiography
Coronary artery
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - ethnology
Coronary vessels
Coronary Vessels - diagnostic imaging
Country of birth
Diabetes
Female
Follow-Up Studies
Health risk assessment
Heart
Humans
Incidence
Lipoprotein(a) - blood
Lipoproteins
Male
Middle Aged
Minority & ethnic groups
Prognosis
Quartiles
Retrospective Studies
Risk analysis
Risk Assessment - methods
Risk Factors
Survival Rate - trends
Thickness
Tomography, X-Ray Computed
United States - epidemiology
Veins & arteries
Asia, Southeastern
United States
North Carolina
Bangladesh
San Francisco California
San Francisco Bay
Pakistan
Myanmar (Burma)
United States > US
Sri Lanka
California
Chicago Illinois
Nepal
India
ISSN:0002-9149, 1879-1913, 1879-1913
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Popis
Shrnutí:We sought to report the distribution of Lp(a) levels in the Mediators of Atherosclerosis among South Asians Living in America cohort of participants who were free from clinical atherosclerotic cardiovascular disease (ASCVD) at baseline and to evaluate the cross-sectional association with atherosclerosis measured by coronary artery calcification (CAC) and carotid intima media thickness. Among 886 participants (mean [SD] age: 55.4 [9.4] years, 54% male), median lipoprotein (a) level was 17 (9, 33) mg/dl. Compared with the lowest quartile (9 mg/dl), subjects in the highest Lp(a) quartile (33 to 178 mg/dl) were more likely to be women (51% vs 37%, p <0.01) and had a higher mean (SD) total cholesterol (193 [37] mg/dl vs 181 [35] mg/dl, p <0.01). CAC was present in 42% and both the presence and degree of CAC was similar across Lp(a) quartiles (p = 0.58). Median Interquartile range (IQR) common and internal carotid intima-media thickness (IMT) thicknesses were 0.84 (0.73, 0.98) mm and 1.12 (0.95, 1.34) mm, respectively, and were also similar across Lp(a) quartiles. After adjustment for cardiovascular risk factors, Lp(a) quartile had no association with prevalent CAC (p = 0.98), internal carotid IMT (p = 0.46), or common carotid IMT (p = 0.97). Among South Asian Americans, mean Lp(a) levels were higher than previous reports among Whites, Hispanic/Latino, and Chinese-Americans but lower than in Blacks. Unlike findings from other race/ethnic groups, Lp(a) levels were not associated with atherosclerosis among South Asian Americans.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
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ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2018.12.013