Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial

Studies done in Asia have shown that a regimen of S-1 plus oxaliplatin (SOX) has promising efficacy and safety in patients with metastatic colorectal cancer. We aimed to establish whether SOX plus bevacizumab is non-inferior to mFOLFOX6 (modified regimen of leucovorin, fluorouracil, and oxaliplatin)...

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Vydané v:	The lancet oncology Ročník 14; číslo 13; s. 1278 - 1286
Hlavní autori:	Yamada, Yasuhide, Takahari, Daisuke, Matsumoto, Hiroshi, Baba, Hideo, Nakamura, Masato, Yoshida, Kazuhiro, Yoshida, Motoki, Iwamoto, Shigeyoshi, Shimada, Ken, Komatsu, Yoshito, Sasaki, Yasutsuna, Satoh, Taroh, Takahashi, Keiichi, Mishima, Hideyuki, Muro, Kei, Watanabe, Masahiko, Sakata, Yuh, Morita, Satoshi, Shimada, Yasuhiro, Sugihara, Kenichi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Ltd 01.12.2013 Elsevier Limited
Predmet:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Cancer therapies Chemotherapy Chemotherapy, Adjuvant Clinical trials Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Creatinine Diarrhea Disease-Free Survival Drug Administration Schedule Drug Combinations Drug dosages Ethics Female Fluorouracil - administration & dosage Hematology, Oncology and Palliative Medicine Humans Infusions, Intravenous Japan Kaplan-Meier Estimate Leucovorin - administration & dosage Male Metastasis Middle Aged Neoplasm Staging Neutrophils Organoplatinum Compounds - administration & dosage Oxonic Acid - administration & dosage Tegafur - administration & dosage Toxicity Treatment Outcome Japan
ISSN:	1470-2045, 1474-5488, 1474-5488
On-line prístup:	Získať plný text
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