Selective EGF-Receptor Inhibition in CD4 + T Cells Induces Anergy and Limits Atherosclerosis

Several epidermal growth factor receptor (EGFR) inhibitors have been successfully developed for the treatment of cancer, limiting tumor growth and metastasis. EGFR is also expressed by leukocytes, but little is known about its role in the modulation of the immune response. The aim of this study was...

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Veröffentlicht in:	Journal of the American College of Cardiology Jg. 71; H. 2; S. 160
Hauptverfasser:	Zeboudj, Lynda, Maître, Mikael, Guyonnet, Lea, Laurans, Ludivine, Joffre, Jeremie, Lemarie, Jeremie, Bourcier, Simon, Nour-Eldine, Wared, Guérin, Coralie, Friard, Jonas, Wakkach, Abdelilah, Fabre, Elizabeth, Tedgui, Alain, Mallat, Ziad, Tharaux, Pierre-Louis, Ait-Oufella, Hafid
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.01.2018
Schlagworte:	Animals Antineoplastic Agents - pharmacology Atherosclerosis - immunology CD4-Positive T-Lymphocytes - immunology Cytokines - analysis Cytokines - classification Cytokines - immunology ErbB Receptors - antagonists & inhibitors Erlotinib Hydrochloride - pharmacology Immunity, Cellular - drug effects Immunity, Cellular - immunology Mice Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - immunology Plaque, Atherosclerotic - pathology Protein Kinase Inhibitors - pharmacology T-Lymphocytes, Regulatory - immunology atherosclerosis immunity inflammation lymphocyte
ISSN:	1558-3597, 1558-3597
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