2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V...

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Vydáno v:	Nature communications Ročník 12; číslo 1; s. 2203 - 16
Hlavní autoři:	Feng, Wei, Han, Xiuguo, Hu, Hui, Chang, Meiqi, Ding, Li, Xiang, Huijing, Chen, Yu, Li, Yuehua
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 13.04.2021 Nature Publishing Group Nature Portfolio
Témata:	13/51 14/19 147/135 147/143 631/61/350 639/301/54/990 639/925/352/152 64/60 Animal models Animals Antioxidants Antioxidants - metabolism Biocompatibility Catalase Catalase - metabolism Cell Line Cell Survival Cytoprotection - drug effects Enzymes Fibroblasts Glutathione Glutathione peroxidase Glutathione Peroxidase - metabolism Haloperoxidase Homeostasis Humanities and Social Sciences Inflammation Mice Mice, Inbred C57BL Mimicry multidisciplinary Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - metabolism Oxidation-Reduction Oxidative stress Oxidative Stress - drug effects Pathogenesis Peroxidase Reactive oxygen species Reactive Oxygen Species - metabolism Science Science (multidisciplinary) Superoxide dismutase Superoxide Dismutase - metabolism Thiol peroxidase Vanadium Vanadium - pharmacology Vanadium carbide X-Ray Diffraction
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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Shrnutí:	Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V 2 C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), thiol peroxidase (TPx) and haloperoxidase (HPO). Based on these enzyme-mimicking properties, the constructed 2D V 2 C MXenzyme not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection against oxidative stress. Importantly, 2D V 2 C MXenzyme rebuilds the redox homeostasis without perturbing the endogenous antioxidant status and relieves ROS-induced damage with benign in vivo therapeutic effects, as demonstrated in both inflammation and neurodegeneration animal models. These findings open an avenue to enable the use of MXenzyme as a remedial nanoplatform to treat ROS-mediated inflammatory and neurodegenerative diseases. Materials with enzymatic-like activities are of interest for a wide range of applications. Here, the authors report on 2D vanadium carbide MXene nanozymes capable of mimicking multiple enzymes and demonstrate application to treat reactive oxygen species-mediated inflammatory and neurodegenerative diseases.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-22278-x