Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of each of the 11 HDAC proteins to the inflammatory gene expression program is unknown. Using an integrated genomic appr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 42; S. E2865
Hauptverfasser:	Chen, Xuefen, Barozzi, Iros, Termanini, Alberto, Prosperini, Elena, Recchiuti, Antonio, Dalli, Jesmond, Mietton, Flore, Matteoli, Gianluca, Hiebert, Scott, Natoli, Gioacchino
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.10.2012
Schlagworte:	Animals Base Sequence Chromatin Immunoprecipitation Cyclooxygenase 1 - metabolism Cytokines - analysis DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Expression Regulation - genetics Genomics Histone Deacetylases - deficiency Histone Deacetylases - metabolism Macrophages - metabolism Membrane Proteins - metabolism Mice Mice, Transgenic Molecular Sequence Data Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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