Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses

Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine produ...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Vol. 140; no. 3; pp. 229 - 235
Main Authors: Hogan, Andrew E., Corrigan, Michelle A., O'Reilly, Vincent, Gaoatswe, Gadintshware, O'Connell, Jean, Doherty, Derek G., Lynch, Lydia, O'Shea, Donal
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Inc 01.09.2011
Elsevier
Subjects:
Allergy and Immunology
Anti-tumor responses
Antigens, CD - biosynthesis
Antigens, CD - immunology
Antigens, Differentiation, T-Lymphocyte - biosynthesis
Antigens, Differentiation, T-Lymphocyte - immunology
Biological and medical sciences
CD56 Antigen - biosynthesis
CD56 Antigen - immunology
Cells, Cultured
Cigarette smoke
Cytokines - biosynthesis
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic - drug effects
Cytotoxicity, Immunologic - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Galactosylceramides - immunology
Galactosylceramides - pharmacology
HeLa Cells
Humans
iNKT cells
Lectins, C-Type - biosynthesis
Lectins, C-Type - immunology
Lymphocyte Activation - drug effects
Lymphocyte Activation - immunology
Lysosomal-Associated Membrane Protein 1 - biosynthesis
Lysosomal-Associated Membrane Protein 1 - immunology
Medical sciences
Natural Killer T-Cells - drug effects
Natural Killer T-Cells - immunology
Neoplasms - immunology
Nicotiana - adverse effects
Smoke - adverse effects
Smoking - immunology
Tobacco, tobacco smoking
Toxicology
Up-Regulation - drug effects
Up-Regulation - immunology
CSE
Anti-tumor responses
iNKT cells
PBMC
αGalCer
iNKT
Cigarette smoke
Invariant natural killer T cell
α-Galactosylceramide
Peripheral blood mononuclear cells
Cigarette smoke extract
Cigarette
Immunology
Tobacco smoking
Tumor
Inhibitor
Cell
ISSN:1521-6616, 1521-7035, 1521-7035
Online Access:Get full text
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Summary:Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine production. Studies show that iNKT cells are defective in certain cancers. Cigarette smoke contains many carcinogens and is implicated directly and indirectly in many cancers. We investigated the effects of cigarette smoke on the circulating iNKT cell number and function. We found that the iNKT cell frequency is significantly reduced in cigarette smoking subjects. Invariant NKT cells exposed to cigarette smoke extract (CSE) showed significant defects in cytokine production and the ability to kill target cells. CSE inhibits the upregulation of CD107 but not CD69 or CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor responses, which may contribute to the role of smoking in the development of cancer.
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ISSN:1521-6616
1521-7035
1521-7035
DOI:10.1016/j.clim.2011.01.011