Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses

Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine produ...

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Vydané v:	Clinical immunology (Orlando, Fla.) Ročník 140; číslo 3; s. 229 - 235
Hlavní autori:	Hogan, Andrew E., Corrigan, Michelle A., O'Reilly, Vincent, Gaoatswe, Gadintshware, O'Connell, Jean, Doherty, Derek G., Lynch, Lydia, O'Shea, Donal
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Amsterdam Elsevier Inc 01.09.2011 Elsevier
Predmet:	Allergy and Immunology Anti-tumor responses Antigens, CD - biosynthesis Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences CD56 Antigen - biosynthesis CD56 Antigen - immunology Cells, Cultured Cigarette smoke Cytokines - biosynthesis Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic - drug effects Cytotoxicity, Immunologic - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Galactosylceramides - immunology Galactosylceramides - pharmacology HeLa Cells Humans iNKT cells Lectins, C-Type - biosynthesis Lectins, C-Type - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lysosomal-Associated Membrane Protein 1 - biosynthesis Lysosomal-Associated Membrane Protein 1 - immunology Medical sciences Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Neoplasms - immunology Nicotiana - adverse effects Smoke - adverse effects Smoking - immunology Tobacco, tobacco smoking Toxicology Up-Regulation - drug effects Up-Regulation - immunology CSE Anti-tumor responses iNKT cells PBMC αGalCer iNKT Cigarette smoke Invariant natural killer T cell α-Galactosylceramide Peripheral blood mononuclear cells Cigarette smoke extract Cigarette Immunology Tobacco smoking Tumor Inhibitor Cell
ISSN:	1521-6616, 1521-7035, 1521-7035
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Popis
Shrnutí:	Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine production. Studies show that iNKT cells are defective in certain cancers. Cigarette smoke contains many carcinogens and is implicated directly and indirectly in many cancers. We investigated the effects of cigarette smoke on the circulating iNKT cell number and function. We found that the iNKT cell frequency is significantly reduced in cigarette smoking subjects. Invariant NKT cells exposed to cigarette smoke extract (CSE) showed significant defects in cytokine production and the ability to kill target cells. CSE inhibits the upregulation of CD107 but not CD69 or CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor responses, which may contribute to the role of smoking in the development of cancer.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1521-6616 1521-7035 1521-7035
DOI:	10.1016/j.clim.2011.01.011