Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses

Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine produ...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Jg. 140; H. 3; S. 229 - 235
Hauptverfasser:	Hogan, Andrew E., Corrigan, Michelle A., O'Reilly, Vincent, Gaoatswe, Gadintshware, O'Connell, Jean, Doherty, Derek G., Lynch, Lydia, O'Shea, Donal
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Amsterdam Elsevier Inc 01.09.2011 Elsevier
Schlagworte:	Allergy and Immunology Anti-tumor responses Antigens, CD - biosynthesis Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences CD56 Antigen - biosynthesis CD56 Antigen - immunology Cells, Cultured Cigarette smoke Cytokines - biosynthesis Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic - drug effects Cytotoxicity, Immunologic - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Galactosylceramides - immunology Galactosylceramides - pharmacology HeLa Cells Humans iNKT cells Lectins, C-Type - biosynthesis Lectins, C-Type - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lysosomal-Associated Membrane Protein 1 - biosynthesis Lysosomal-Associated Membrane Protein 1 - immunology Medical sciences Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Neoplasms - immunology Nicotiana - adverse effects Smoke - adverse effects Smoking - immunology Tobacco, tobacco smoking Toxicology Up-Regulation - drug effects Up-Regulation - immunology CSE Anti-tumor responses iNKT cells PBMC αGalCer iNKT Cigarette smoke Invariant natural killer T cell α-Galactosylceramide Peripheral blood mononuclear cells Cigarette smoke extract Cigarette Immunology Tobacco smoking Tumor Inhibitor Cell
ISSN:	1521-6616, 1521-7035, 1521-7035
Online-Zugang:	Volltext
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