Line-Field Confocal Optical Coherence Tomography: A New Skin Imaging Technique Reproducing a “Virtual Biopsy” with Evolving Clinical Applications in Dermatology

Background: Line-field confocal optical coherence tomography is a novel technology able to reproduce a “virtual biopsy” of the skin. The aim of this review is to explore the application of line-field confocal optical coherence tomography (LC-OCT) in various skin diseases, covering skin cancers, infl...

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Published in:Diagnostics (Basel) Vol. 14; no. 16; p. 1821
Main Authors: Cappilli, Simone, Paradisi, Andrea, Di Stefani, Alessandro, Palmisano, Gerardo, Pellegrino, Luca, D’Onghia, Martina, Ricci, Costantino, Tognetti, Linda, Verzì, Anna Elisa, Rubegni, Pietro, Del Marmol, Veronique, Lacarrubba, Francesco, Cinotti, Elisa, Suppa, Mariano, Peris, Ketty
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.08.2024
MDPI
Subjects:
Accuracy
Biopsy
clinical dermatology
Dermatology
Diagnosis
diagnostic imaging
histology of the skin
Histopathology
line-field confocal optical coherence tomography
Medical equipment
Melanoma
Methods
Optical tomography
review
Skin cancer
Skin diseases
Software
Systematic Review
Tomography
virtual biopsy
Italy
line-field confocal optical coherence tomography
virtual biopsy
clinical dermatology
review
diagnostic imaging
histology of the skin
ISSN:2075-4418, 2075-4418
Online Access:Get full text
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Summary:Background: Line-field confocal optical coherence tomography is a novel technology able to reproduce a “virtual biopsy” of the skin. The aim of this review is to explore the application of line-field confocal optical coherence tomography (LC-OCT) in various skin diseases, covering skin cancers, inflammatory and infectious skin diseases, genetic diseases, cosmetic procedures, and less common disorders. Methods: Study selection was conducted based on LC-OCT and using pertinent MeSh terms, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines from inception to March 2024; to evaluate the quality and risk of bias of studies, Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used. Results: the search retrieved 154 papers according to the selection criteria; after removing publications by one or more of the exclusion criteria, a total of 96 studies were found to be suitable for the analysis. Conclusions: Increasing evidence supports the use of LC-OCT as an adjunctive diagnostic tool for the in vivo diagnosis of a variety of skin tumors. As this device can be considered a “bridge” between dermoscopy and histopathology, widening applications in numerous fields of clinical dermatology, including inflammatory skin disease treatment, presurgical mapping, cosmetic procedures, and monitoring of non-invasive therapies, have been explored.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14161821