Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor

Pamiparib, an investigational Poly (ADP-ribose) polymerase (PARP) inhibitor in clinical development, demonstrates excellent selectivity for both PARP1 and PARP2, and superb anti-proliferation activities in tumor cell lines with BRCA1/2 mutations or HR pathway deficiency (HRD). Pamiparib has good bio...

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Veröffentlicht in:	Neoplasia (New York, N.Y.) Jg. 22; H. 9; S. 431 - 440
Hauptverfasser:	Xiong, Yao, Guo, Yin, Liu, Ye, Wang, Hexiang, Gong, Wenfeng, Liu, Yong, Wang, Xing, Gao, Yajuan, Yu, Fenglong, Su, Dan, Wang, Fan, Zhu, Yutong, Zhao, Yuan, Wu, Yiyuan, Qin, Zhen, Sun, Xuebing, Ren, Bo, Jiang, Bin, Jin, Wei, Shen, Zhirong, Tang, Zhiyu, Song, Xiaomin, Wang, Lai, Liu, Xuesong, Zhou, Changyou, Jiang, Beibei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.09.2020 Neoplasia Press Elsevier
Schlagworte:	Brain penetration Original article Pamiparib PARP TMZ TMZ PARP Brain penetration Pamiparib
ISSN:	1476-5586, 1522-8002, 1476-5586
Online-Zugang:	Volltext
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