Understanding the prion-like behavior of mutant p53 proteins in triple-negative breast cancer pathogenesis: The current therapeutic strategies and future directions

Breast cancer (BC) is viewed as a significant public health issue and is the primary cause of cancer-related deaths among women worldwide. Triple-negative breast cancer (TNBC) is a particularly aggressive subtype that predominantly affects young premenopausal women. The tumor suppressor p53 playsa v...

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Bibliographic Details
Published in:	Heliyon Vol. 10; no. 4; p. e26260
Main Authors:	Naeimzadeh, Yasaman, Tajbakhsh, Amir, Fallahi, Jafar
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 29.02.2024 Elsevier
Subjects:	breast neoplasms cancer therapy Cancer treatment CRISPR-Cas systems DNA damage epidemiology immunotherapy Mutant p53 mutants pathogenesis premenopause Prion-like aggregation public health Review Triple-negative breast cancer Mutant p53 Cancer treatment Prion-like aggregation Triple-negative breast cancer
ISSN:	2405-8440, 2405-8440
Online Access:	Get full text
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