Acute effects of pharmacological modifications of fatty acid metabolism on human satiety

The role of NEFA in eating behaviour is still poorly known. Our objective was to examine whether etomoxir (ETO), an inhibitor of NEFA oxidation, or ( − )-hydroxycitrate (HCA), an inhibitor of lipogenesis which may indirectly stimulate NEFA oxidation, alters satiety. Post-lunch satiety was measured i...

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Vydáno v:	British journal of nutrition Ročník 101; číslo 12; s. 1867 - 1877
Hlavní autoři:	Gatta, Blandine, Zuberbuehler, Christine, Arnold, Myrtha, Aubert, Roberte, Langhans, Wolfgang, Chapelot, Didier
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cambridge, UK Cambridge University Press 28.06.2009
Témata:	( − )-Hydroxycitrate 3-Hydroxybutyric Acid 3-Hydroxybutyric Acid - blood Adult analysis Analysis of Variance Appetite Area Under Curve Biological and medical sciences Biomarkers Biomarkers - blood Blood Blood Glucose Blood Glucose - analysis blood plasma Citrates Citrates - pharmacology diet dinner drug effects drug evaluation Eating Eating behavior eating habits Energy Intake enzyme inhibitors Epoxy Compounds Epoxy Compounds - pharmacology etomoxir Fatty acid oxidation fatty acids Fatty Acids, Nonesterified Fatty Acids, Nonesterified - metabolism Feeding. Feeding behavior food intake Fundamental and applied biological sciences. Psychology ghrelin Ghrelin - blood glucose Humans Hunger hydroxycitrate Hypoglycemic Agents Hypoglycemic Agents - pharmacology ideal body weight insulin Insulin - blood lactates Lactic Acid Lactic Acid - blood Leptin Leptin - blood Lipid Metabolism Lipid Metabolism - drug effects lipogenesis lipolysis lunch Male men metabolism NEFA non-essential fatty acids Oxidation pharmacology Satiation Satiation - drug effects satiety Single-Blind Method Triglycerides Triglycerides - analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult Fatty acid oxidation Eating ( − )-Hydroxycitrate NEFA Leptin Human Modification Acute Lipids Metabolism Fatty acids Vertebrata Mammalia (―)-Hydroxycitrate Satiety Oxidation
ISSN:	0007-1145, 1475-2662, 1475-2662
On-line přístup:	Získat plný text
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Shrnutí:	The role of NEFA in eating behaviour is still poorly known. Our objective was to examine whether etomoxir (ETO), an inhibitor of NEFA oxidation, or ( − )-hydroxycitrate (HCA), an inhibitor of lipogenesis which may indirectly stimulate NEFA oxidation, alters satiety. Post-lunch satiety was measured in eight normal-weight male subjects who were deprived of time cues and received on three occasions either ETO (320 mg), HCA (2 g) or placebo (PLA) in random order. Between lunch and dinner, blood was withdrawn continuously and collected every 10 min for measures of plasma concentrations of glucose, insulin, lactate, TAG, NEFA, β-hydroxybutyrate (BHB), leptin and ghrelin. Results showed that HCA began to decrease hunger and desire to eat compared to PLA and ETO 210 min after lunch and increased satiety duration compared to PLA by 70 (se 23) min (P < 0·05), but did not modify energy intake at dinner. ETO did not affect any variable of satiety. HCA increased NEFA concentrations during the pre-dinner period, whereas ETO increased and decreased plasma concentrations of NEFA and BHB, respectively. Mean differences in plasma NEFA concentrations between HCA and PLA were predictive of the differences in satiety duration between treatments (r2 0·71, P < 0·01). Among treatments, plasma leptin concentration at dinner onset was the only blood variable correlated with energy intake at this meal (r − 0·75, P < 0·0005). In healthy, normal-weight men, acute HCA increased the intensity and duration of satiety possibly via increased NEFA disposal for oxidation.
Bibliografie:	http://dx.doi.org/10.1017/S0007114508143604 ark:/67375/6GQ-19R45H94-6 ArticleID:14360 istex:ACBEAA3ACF9490211708C49FA621E7D57326AA3B PII:S0007114508143604 Abbreviations: AUC, area under the curve; BHB, β-hydroxybutyrate; ETO, etomoxir; HCA, ( − )-hydroxycitrate; IMI, inter-meal interval; PLA, placebo ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0007-1145 1475-2662 1475-2662
DOI:	10.1017/S0007114508143604