DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis

DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism. As we review here, current structural approaches have revealed unprecedented insights into the complex DNA‐topoisomerase interac...

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Bibliographic Details
Published in:	BioEssays Vol. 43; no. 4; pp. e2000286 - n/a
Main Authors:	McKie, Shannon J., Neuman, Keir C., Maxwell, Anthony
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.04.2021
Subjects:	antibiotics anti‐cancer drugs Cellular structure Deoxyribonucleic acid dissection DNA DNA gyrase DNA structure DNA supercoiling DNA topoisomerase DNA Topoisomerases DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - metabolism Function analysis In vivo methods and tests Metabolism Protein structure Proteins Structure-function relationships Topology DNA supercoiling anti-cancer drugs DNA gyrase antibiotics DNA topoisomerase
ISSN:	0265-9247, 1521-1878, 1521-1878
Online Access:	Get full text
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