Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling

Mec1-Ddc2 (ATR-ATRIP) controls the DNA damage checkpoint and shows differential cell-cycle regulation in yeast. To find regulators of Mec1-Ddc2, we exploited a mec1 mutant that retains catalytic activity in G2 and recruitment to stalled replication forks, but which is compromised for the intra-S pha...

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Vydané v:	Molecular cell Ročník 57; číslo 2; s. 273
Hlavní autori:	Hustedt, Nicole, Seeber, Andrew, Sack, Ragna, Tsai-Pflugfelder, Monika, Bhullar, Bhupinder, Vlaming, Hanneke, van Leeuwen, Fred, Guénolé, Aude, van Attikum, Haico, Srivas, Rohith, Ideker, Trey, Shimada, Kenji, Gasser, Susan M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 22.01.2015
Predmet:	Adaptor Proteins, Signal Transducing - metabolism Cell Cycle Checkpoints Cell Cycle Proteins - metabolism Checkpoint Kinase 2 - metabolism DNA Replication Epistasis, Genetic Gene Expression Regulation, Fungal HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Nuclear Proteins - metabolism Phosphoprotein Phosphatases - metabolism Phosphorylation Protein Processing, Post-Translational Protein Serine-Threonine Kinases - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - metabolism Signal Transduction
ISSN:	1097-4164, 1097-4164
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