Fisetin is a senotherapeutic that extends health and lifespan

Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated that the combina...

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Veröffentlicht in:	EBioMedicine Jg. 36; S. 18 - 28
Hauptverfasser:	Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.10.2018 Elsevier
Schlagworte:	Adipose Tissue - metabolism Advanced Basic Science Aging Animals Biological Products - pharmacology Biological Products - therapeutic use Biomarkers Cellular Senescence - drug effects Cellular Senescence - genetics Female Fibroblasts - drug effects Fibroblasts - metabolism Flavonoids - pharmacology Flavonoids - therapeutic use Flavonols Gene Expression Genes, Reporter Health Status Healthspan Humans Internal Medicine Lifespan Lipid Peroxidation Longevity - drug effects Male Mice Mice, Knockout Progeria Research paper Senescence Senolytic Aging Senescence Healthspan Lifespan Senolytic Progeria
ISSN:	2352-3964, 2352-3964
Online-Zugang:	Volltext
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