Osteoprotegerin Is Associated With Silent Coronary Artery Disease in High-Risk but Asymptomatic Type 2 Diabetic Patients

OBJECTIVE:--Osteoprotegerin (OPG) is an inhibitor of osteoclastogenesis, which has been recently involved in atherosclerosis. The relationship between coronary atherosclerosis and OPG has never been studied in asymptomatic type 2 diabetic patients. RESEARCH DESIGN AND METHODS--This is a nested case-...

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Vydáno v:	Diabetes care Ročník 28; číslo 9; s. 2176 - 2180
Hlavní autoři:	Avignon, Antoine, Sultan, Ariane, Piot, Christophe, Elaerts, Stéphane, Cristol, Jean Paul, Dupuy, Anne Marie
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Alexandria, VA American Diabetes Association 01.09.2005
Témata:	adiponectin Adrenergic beta-Agonists Aged analysis Associated diseases and complications Atherosclerosis Biological and medical sciences Biomarkers Biomarkers - blood blood C-reactive protein Cardiology. Vascular system Cardiovascular disease case-control studies Cholesterol Complications and side effects coronary artery disease Coronary Disease Coronary Disease - blood Coronary Disease - diagnosis Coronary Disease - epidemiology Coronary heart disease Diabetes Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Diabetic Angiopathies Diabetic Angiopathies - blood Diabetic Angiopathies - diagnosis Diabetic Angiopathies - epidemiology diagnosis diagnostic use Dipyridamole Electrocardiography Endocrine pancreas. Apud cells (diseases) Endocrinopathies epidemiology Exercise Test Female Glycated Hemoglobin Glycated Hemoglobin A - analysis Glycoproteins Glycoproteins - blood Health risk assessment Heart high density lipoprotein cholesterol Humans image analysis kidney diseases Lipids Lipids - blood low density lipoprotein cholesterol Male Medical imaging Medical sciences Middle Aged Multivariate Analysis noninsulin-dependent diabetes mellitus odds ratio Osteoprotegerin patients Physiological aspects Platelet Aggregation Inhibitors Receptors, Cytoplasmic and Nuclear Receptors, Cytoplasmic and Nuclear - blood Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor - blood regression analysis Risk Factors Type 2 diabetes France Endocrinopathy Vascular disease Type 2 diabetes Human High risk Atherosclerosis Cardiovascular disease Metabolic diseases Complication Asymptomatic Coronary heart disease Osteoprotegerin
ISSN:	0149-5992, 1935-5548
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Shrnutí:	OBJECTIVE:--Osteoprotegerin (OPG) is an inhibitor of osteoclastogenesis, which has been recently involved in atherosclerosis. The relationship between coronary atherosclerosis and OPG has never been studied in asymptomatic type 2 diabetic patients. RESEARCH DESIGN AND METHODS--This is a nested case-control study; 162 asymptomatic type 2 diabetic patients were evaluated for silent myocardial ischemia using stress myocardial perfusion imaging; of 50 patients with positive results, 37 underwent coronary angiography, 20 of whom showed significant coronary artery disease (CAD group). Of 112 patients without silent myocardial ischemia, 20 subjects (NO-CAD group) were selected and matched by age and sex to patients with CAD. OPG, C-reactive protein, adiponectin, lipoprotein(a), albuminuria, and classical risk factors were measured. RESULTS:--The percentages of subjects with OPG levels above median and with nephropathy were higher in the CAD group than in the NO-CAD group (70 vs. 25%, P = 0.004 and 50 vs. 5%, P = 0.001, respectively). LDL cholesterol levels were higher and HDL cholesterol levels lower in the CAD compared with the NO-CAD group (P = 0.033 and P = 0.005, respectively). No other variables were associated with CAD. Logistic regression analysis showed that OPG values above median (odds ratio 8.31 [95% CI 1.18-58.68], P = 0.034) and nephropathy (21.98 [1.24-388.36], P = 0.035) were significant independent predictors of asymptomatic CAD in type 2 diabetic patients. CONCLUSIONS:--Our investigation reports the first evidence of an independent association of OPG with asymptomatic CAD in type 2 diabetic patients. The results of this nested case- control study with 20 cases need to be confirmed in a larger population.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0149-5992 1935-5548
DOI:	10.2337/diacare.28.9.2176