Increased leptin and A-FABP levels in relapsing and progressive forms of MS

Background Leptin and adipocyte-fatty acid binding protein (A-FABP) are produced by white adipose tissue and may play a role in chronic inflammation in Multiple Sclerosis (MS). To assess leptin and A-FABP in relapsing and progressive forms of MS. Methods Adipokine levels were measured in untreated a...

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Published in:BMC neurology Vol. 13; no. 1; p. 172
Main Authors: Messina, Silvia, Vargas-Lowy, David, Musallam, Alexander, Healy, Brian C, Kivisakk, Pia, Gandhi, Roopali, Bove, Riley, Gholipour, Taha, Khoury, Samia, Weiner, Howard L, Chitnis, Tanuja
Format: Journal Article
Language:English
Published: London BioMed Central 11.11.2013
BioMed Central Ltd
Springer Nature B.V
Subjects:
Adipose tissues
Adolescent
Adult
Binding proteins
Body mass index
Case-Control Studies
Child
Demyelinating diseases
Development and progression
Enzyme-Linked Immunosorbent Assay
Female
Humans
Inflammation
Leptin
Leptin - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Chronic Progressive - blood
Multiple Sclerosis, Relapsing-Remitting - blood
Neurochemistry
Neurology
Neurosurgery
Pediatrics
Pharmaceutical industry
Physiological aspects
Research Article
Studies
Womens health
United States
Switzerland
Massachusetts
175. Neuroendocrinology
41. Multiple sclerosis
132. Autoimmune disease
ISSN:1471-2377, 1471-2377
Online Access:Get full text
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Summary:Background Leptin and adipocyte-fatty acid binding protein (A-FABP) are produced by white adipose tissue and may play a role in chronic inflammation in Multiple Sclerosis (MS). To assess leptin and A-FABP in relapsing and progressive forms of MS. Methods Adipokine levels were measured in untreated adult relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS) and Healthy control (HC). Pediatric-onset MS (POMS) and pediatric healthy controls (PHC) were also assessed. Leptin and A-FABP levels were measured in serum by ELISA. Groups were compared using linear mixed-effects model. Results Excluding two patients with Body Mass Index (BMI) > 50, a significant difference in leptin level was found between RRMS and HC controlling for age (p = 0.007), SPMS and HC controlling for age alone (p = 0.002), or age and BMI (p = 0.007). A-FABP levels were higher in SPMS than HC (p = 0.007), controlling for age and BMI. Differences in A-FABP levels between POMS and PHC was observed after controlling for age (p = 0.019), but not when BMI was added to the model (p = 0.081). Conclusion Leptin and A-FABP levels are highest in SPMS compared to HC, suggesting a role in pathogenesis of this disease subtype. A-FABP levels are increased in POMS patients and may play a role in the early stages of disease.
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ISSN:1471-2377
1471-2377
DOI:10.1186/1471-2377-13-172