Comparison of CT volumetric measurement with RECIST response in patients with lung cancer

To examine the correlations between uni-dimensional RECIST and volumetric measurements in patients with lung adenocarcinoma and to assess their association with overall survival (OS) and progression-free survival (PFS). In this study of patients receiving chemotherapy for lung cancer in the setting...

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Veröffentlicht in:European journal of radiology Jg. 85; H. 3; S. 524 - 533
Hauptverfasser: Hayes, S.A., Pietanza, M.C., O’Driscoll, D., Zheng, J., Moskowitz, C.S., Kris, M.G., Ginsberg, M.S.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Ireland Elsevier Ireland Ltd 01.03.2016
Schlagworte:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma of Lung
Adult
Aged
Computed tomography
Cone-Beam Computed Tomography - methods
Disease-Free Survival
Female
Humans
Lung - diagnostic imaging
Lung cancer
Lung Neoplasms - diagnostic imaging
Male
Middle Aged
Prospective Studies
Radiology
RECIST
Response
Response Evaluation Criteria in Solid Tumors
Retrospective Studies
Treatment Outcome
Volumetric
Response
RECIST
Volumetric
Computed tomography
Lung cancer
ISSN:0720-048X, 1872-7727, 1872-7727
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Zusammenfassung:To examine the correlations between uni-dimensional RECIST and volumetric measurements in patients with lung adenocarcinoma and to assess their association with overall survival (OS) and progression-free survival (PFS). In this study of patients receiving chemotherapy for lung cancer in the setting of a clinical trial, response was prospectively evaluated using RECIST 1.0. Retrospectively, volumetric measurements were recorded and response was assessed by two different volumetric methods at each followup CT scan using a semi-automated segmentation algorithm. We subsequently evaluated the correlation between the uni-dimensional RECIST measurements and the volumetric measurements and performed landmark analyses for OS and PFS at the completion of the first and second follow-ups. Kaplan–Meier curves together with log-rank tests were used to evaluate the association between the different response criteria and patient outcome. Forty-two patients had CT scans at baseline, after the first follow up scan and second followup scan, and then every 8 weeks. The uni-dimensional RECIST measurements and volumetric measurements were strongly correlated, with a Spearman correlation coefficient (ρ) of 0.853 at baseline, ρ=0.861 at the first followup, ρ=0.843 at the 2nd followup, and ρ=0.887 overall between-subject. On first follow-up CT, partial responders and non responders as assessed by an “ellipsoid” volumetric criteria showed a significant difference in OS (p=0.008, 1-year OS of 70% for partial responders and 46% for non responders). There was no difference between the groups when assessed by RECIST criteria on first follow-up CT (p=0.841, 1-year OS rate of 64% for partial responders and 64% for non responders). Volumetric response on first follow-up CT may better predict OS than RECIST response. Assessment of tumor size and response is of utmost importance in clinical trials. Volumetric measurements may help to better predict OS than uni-dimensional RECIST criteria.
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ISSN:0720-048X
1872-7727
1872-7727
DOI:10.1016/j.ejrad.2015.12.019