Development of a clinically relevant ovarian cancer model incorporating surgical cytoreduction to evaluate treatment of micro-metastatic disease

Mouse models of ovarian cancer commonly transfer large numbers of tumor cells into the peritoneal cavity to establish experimental metastatic disease, which may not adequately model early metastatic spread from a primary tumor site. We hypothesized we could develop an ovarian cancer model that predi...

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Bibliographic Details
Published in:	Gynecologic oncology Vol. 160; no. 2; pp. 427 - 437
Main Authors:	Morse, Christopher B., Voillet, Valentin, Bates, Breanna M., Chiu, Edison Y., Garcia, Nicolas M., Gottardo, Raphael, Greenberg, Philip D., Anderson, Kristin G.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2021
Subjects:	Animals Cell Line, Tumor - transplantation Cytoreduction Surgical Procedures Disease Models, Animal Female Hematology, Oncology, and Palliative Medicine Humans Hysterectomy Mice Neoplasm Micrometastasis - therapy Neoplasm, Residual Obstetrics and Gynecology Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Ovary - pathology Ovary - surgery Peritoneal Cavity - pathology Peritoneal Cavity - surgery Peritoneal Neoplasms - secondary Peritoneal Neoplasms - surgery Salpingo-oophorectomy Tumor Burden
ISSN:	0090-8258, 1095-6859, 1095-6859
Online Access:	Get full text
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