p53 Modulates Radiosensitivity in Head and Neck Cancers—From Classic to Future Horizons

p53, initially considered a tumor suppressor, has been the subject of research related to cancer treatment resistance in the last 30 years. The unfavorable response to multimodal therapy and the higher recurrence rate, despite an aggressive approach, make HNSCC a research topic of interest for impro...

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Published in:Diagnostics (Basel) Vol. 12; no. 12; p. 3052
Main Authors: Mireștean, Camil Ciprian, Iancu, Roxana Irina, Iancu, Dragoș Petru Teodor
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.12.2022
MDPI
Subjects:
Apoptosis
Biomarkers
Cancer therapies
Care and treatment
Cell cycle
Cell division
Chemotherapy
DNA damage
Head & neck cancer
Head and neck cancer
head and neck cancers
Health aspects
HNSCC
Kinases
Metabolism
Methods
Mutation
Ovarian cancer
p53
Phase transitions
Radiation
radioresistance
radiosensitivity
Radiotherapy
Review
Tumor proteins
Tumors
Romania
radiotherapy
head and neck cancers
HNSCC
radioresistance
radiosensitivity
p53
ISSN:2075-4418, 2075-4418
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Abstract p53, initially considered a tumor suppressor, has been the subject of research related to cancer treatment resistance in the last 30 years. The unfavorable response to multimodal therapy and the higher recurrence rate, despite an aggressive approach, make HNSCC a research topic of interest for improving therapeutic outcomes, even if it is only the sixth most common malignancy worldwide. New advances in molecular biology and genetics include the involvement of miRNA in the control of the p53 pathway, the understanding of mechanisms such as gain/loss of function, and the development of different methods to restore p53 function, especially for HPV-negative cases. The different ratio between mutant p53 status in the primary tumor and distant metastasis originating HNSCC may serve to select the best therapeutic target for activating an abscopal effect by radiotherapy as a “booster” of the immune system. P53 may also be a key player in choosing radiotherapy fractionation regimens. Targeting any pathway involving p53, including tumor metabolism, in particular the Warburg effect, could modulate the radiosensitivity and chemo-sensitivity of head and neck cancers.
AbstractList p53, initially considered a tumor suppressor, has been the subject of research related to cancer treatment resistance in the last 30 years. The unfavorable response to multimodal therapy and the higher recurrence rate, despite an aggressive approach, make HNSCC a research topic of interest for improving therapeutic outcomes, even if it is only the sixth most common malignancy worldwide. New advances in molecular biology and genetics include the involvement of miRNA in the control of the p53 pathway, the understanding of mechanisms such as gain/loss of function, and the development of different methods to restore p53 function, especially for HPV-negative cases. The different ratio between mutant p53 status in the primary tumor and distant metastasis originating HNSCC may serve to select the best therapeutic target for activating an abscopal effect by radiotherapy as a "booster" of the immune system. P53 may also be a key player in choosing radiotherapy fractionation regimens. Targeting any pathway involving p53, including tumor metabolism, in particular the Warburg effect, could modulate the radiosensitivity and chemo-sensitivity of head and neck cancers.p53, initially considered a tumor suppressor, has been the subject of research related to cancer treatment resistance in the last 30 years. The unfavorable response to multimodal therapy and the higher recurrence rate, despite an aggressive approach, make HNSCC a research topic of interest for improving therapeutic outcomes, even if it is only the sixth most common malignancy worldwide. New advances in molecular biology and genetics include the involvement of miRNA in the control of the p53 pathway, the understanding of mechanisms such as gain/loss of function, and the development of different methods to restore p53 function, especially for HPV-negative cases. The different ratio between mutant p53 status in the primary tumor and distant metastasis originating HNSCC may serve to select the best therapeutic target for activating an abscopal effect by radiotherapy as a "booster" of the immune system. P53 may also be a key player in choosing radiotherapy fractionation regimens. Targeting any pathway involving p53, including tumor metabolism, in particular the Warburg effect, could modulate the radiosensitivity and chemo-sensitivity of head and neck cancers.
p53, initially considered a tumor suppressor, has been the subject of research related to cancer treatment resistance in the last 30 years. The unfavorable response to multimodal therapy and the higher recurrence rate, despite an aggressive approach, make HNSCC a research topic of interest for improving therapeutic outcomes, even if it is only the sixth most common malignancy worldwide. New advances in molecular biology and genetics include the involvement of miRNA in the control of the p53 pathway, the understanding of mechanisms such as gain/loss of function, and the development of different methods to restore p53 function, especially for HPV-negative cases. The different ratio between mutant p53 status in the primary tumor and distant metastasis originating HNSCC may serve to select the best therapeutic target for activating an abscopal effect by radiotherapy as a “booster” of the immune system. P53 may also be a key player in choosing radiotherapy fractionation regimens. Targeting any pathway involving p53, including tumor metabolism, in particular the Warburg effect, could modulate the radiosensitivity and chemo-sensitivity of head and neck cancers.
Audience Academic
Author Iancu, Roxana Irina
Mireștean, Camil Ciprian
Iancu, Dragoș Petru Teodor
AuthorAffiliation 1 Department of Oncology and Radiotherapy, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
5 Oncology and Radiotherapy Department, Faculty of Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
4 Department of Clinical Laboratory, “St. Spiridon” Emergency Universitary Hospital, 700111 Iași, Romania
3 Oral Pathology Department, Faculty of Dental Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
2 Department of Surgery, Railways Clinical Hospital Iasi, 700506 Iași, Romania
6 Department of Radiation Oncology, Regional Institute of Oncology, 700483 Iași, Romania
AuthorAffiliation_xml – name: 2 Department of Surgery, Railways Clinical Hospital Iasi, 700506 Iași, Romania
– name: 4 Department of Clinical Laboratory, “St. Spiridon” Emergency Universitary Hospital, 700111 Iași, Romania
– name: 6 Department of Radiation Oncology, Regional Institute of Oncology, 700483 Iași, Romania
– name: 1 Department of Oncology and Radiotherapy, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
– name: 3 Oral Pathology Department, Faculty of Dental Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
– name: 5 Oncology and Radiotherapy Department, Faculty of Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
Author_xml – sequence: 1
  givenname: Camil Ciprian
  orcidid: 0000-0001-6212-8008
  surname: Mireștean
  fullname: Mireștean, Camil Ciprian
– sequence: 2
  givenname: Roxana Irina
  surname: Iancu
  fullname: Iancu, Roxana Irina
– sequence: 3
  givenname: Dragoș Petru Teodor
  surname: Iancu
  fullname: Iancu, Dragoș Petru Teodor
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36553058$$D View this record in MEDLINE/PubMed
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Issue 12
Keywords radiotherapy
head and neck cancers
HNSCC
radioresistance
radiosensitivity
p53
Language English
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Snippet p53, initially considered a tumor suppressor, has been the subject of research related to cancer treatment resistance in the last 30 years. The unfavorable...
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SubjectTerms Apoptosis
Biomarkers
Cancer therapies
Care and treatment
Cell cycle
Cell division
Chemotherapy
DNA damage
Head & neck cancer
Head and neck cancer
head and neck cancers
Health aspects
HNSCC
Kinases
Metabolism
Methods
Mutation
Ovarian cancer
p53
Phase transitions
Radiation
radioresistance
radiosensitivity
Radiotherapy
Review
Tumor proteins
Tumors
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Title p53 Modulates Radiosensitivity in Head and Neck Cancers—From Classic to Future Horizons
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