Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle

To assess whether there is a difference in the ongoing pregnancy rate after transferring frozen-thawed embryos in natural cycles with spontaneous LH-P rise compared with natural cycles controlled by hCG for final oocyte maturation and ovulation. Randomized controlled trial. Tertiary referral center....

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Vydané v:Fertility and sterility Ročník 94; číslo 6; s. 2054
Hlavní autori: Fatemi, Human Mousavi, Kyrou, Dimitra, Bourgain, Claire, Van den Abbeel, Etienne, Griesinger, Georg, Devroey, Paul
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.11.2010
Predmet:
Adult
Blastocyst
Chorionic Gonadotropin - adverse effects
Chorionic Gonadotropin - blood
Chorionic Gonadotropin - pharmacology
Chorionic Gonadotropin - therapeutic use
Cryopreservation
Embryo Transfer - methods
Female
Fertilization in Vitro - methods
Humans
Luteinizing Hormone - blood
Menstrual Cycle - blood
Menstrual Cycle - drug effects
Menstrual Cycle - physiology
Ovulation Induction - adverse effects
Pregnancy
Pregnancy Rate
Quality Control
ISSN:1556-5653, 1556-5653
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Popis
Shrnutí:To assess whether there is a difference in the ongoing pregnancy rate after transferring frozen-thawed embryos in natural cycles with spontaneous LH-P rise compared with natural cycles controlled by hCG for final oocyte maturation and ovulation. Randomized controlled trial. Tertiary referral center. A total of 168 patients were assigned randomly to undergo frozen ET on day 3 from October 2007 until November 2008. Finally, analysis was performed in 124 patients; 61 belonged to the spontaneous LH group and 63 to the hCG group. In the spontaneous LH group the transfer was planned 5 days after the LH surge. In the hCG group, the cryopreserve ET was planned 5 days after the administration of 5000 IU of hCG, when an endometrial thickness of ≥7 mm and a follicle of ≥17 mm were present on ultrasound examination. Ongoing pregnancy rate. The study was terminated early, when a prespecified interim analysis found a significantly higher ongoing pregnancy rate in the spontaneous LH group as compared with the hCG group (31.1% vs. 14.3%; difference 16.9%, 95% confidence interval 4.4%-28.8%). The results suggest the superiority of the natural cycle as compared with the natural cycle controlled by hCG administration in cryothawed ET cycles.
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ISSN:1556-5653
1556-5653
DOI:10.1016/j.fertnstert.2009.11.036