High-Speed MALDI-TOF Imaging Mass Spectrometry: Rapid Ion Image Acquisition and Considerations for Next Generation Instrumentation

A prototype matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometer has been used for high-speed ion image acquisition. The instrument incorporates a Nd:YLF solid state laser capable of pulse repetition rates up to 5 kHz and continuous laser raster sampling for high-...

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Vydáno v:	Journal of the American Society for Mass Spectrometry Ročník 22; číslo 6; s. 1022 - 1031
Hlavní autoři:	Spraggins, Jeffrey M., Caprioli, Richard M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer-Verlag 01.06.2011 Elsevier Springer Nature B.V
Témata:	Analytical Chemistry Angiotensin II - chemistry Animals Bioinformatics Biological and medical sciences Biotechnology Brain Brain Chemistry Chemistry Chemistry and Materials Science Data acquisition Desorption Focus: MALDI-TOF and Biological MS: Research Article High speed Image acquisition Image Processing, Computer-Assisted - methods Imaging Instruments Investigative techniques, diagnostic techniques (general aspects) Ionization Ions Lasers Lipids - chemistry Mass spectrometry Medical sciences Miscellaneous. Technology New technology Organic Chemistry Oversampling Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteomics Raster Rats Repetition Sampling Scientific imaging Signal Processing, Computer-Assisted Solid state lasers Spatial resolution Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectroscopy Microprobe MALDI Imaging Lipids TOF Mass spectrometry Continuous laser raster Rat Signal sampling Rodentia Central nervous system Raster Imaging mass spectrometry Instrumentation Matrix assisted laser desorption ionization Encephalon Vertebrata Data acquisition system Mammalia Time of flight method Animal CW laser
ISSN:	1044-0305, 1879-1123, 1879-1123
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