Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation. Succinate is an innate immunity signal The bacterial endotoxin lipopolysaccharide activates macrophages, as part of the innate immunity response, by inducing a...

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Bibliographic Details
Published in:	Nature (London) Vol. 496; no. 7444; pp. 238 - 242
Main Authors:	Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S., Beasley, F. C., Cummins, E., Nizet, V., Whyte, M., Taylor, C. T., Lin, H., Masters, S. L., Gottlieb, E., Kelly, V. P., Clish, C., Auron, P. E., Xavier, R. J., O’Neill, L. A. J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.04.2013 Nature Publishing Group
Subjects:	631/45/320 Animals Bone Marrow Cells - cytology Citric Acid Cycle - drug effects Deoxyglucose - pharmacology Down-Regulation - drug effects gamma-Aminobutyric Acid - metabolism Genes, Mitochondrial - drug effects Genes, Mitochondrial - genetics Glutamine - metabolism Glycolysis - drug effects Glycolysis - genetics Health aspects Humanities and Social Sciences Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunity, Innate - drug effects Inflammation Inflammation - metabolism Interleukin-1beta - biosynthesis Interleukin-1beta - genetics Interleukins letter Lipopolysaccharides - pharmacology Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice multidisciplinary Physiological aspects Science Signal Transduction Succinates Succinic Acid - metabolism Up-Regulation - drug effects
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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