Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis

Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are based on restricted evidence. We aimed to assess existing...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:The Lancet infectious diseases Ročník 12; číslo 6; s. 449 - 456
Hlavní autoři: Ettehad, Dena, Schaaf, H Simon, Seddon, James A, Cooke, Graham S, Ford, Nathan
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Elsevier Ltd 01.06.2012
Lancet Publishing Group
Elsevier Limited
Témata:
Antitubercular Agents - adverse effects
Antitubercular Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
Child
Children
Drug resistance
Hearing loss
Human bacterial diseases
Humans
Hypothyroidism
Infectious Disease
Infectious diseases
Medical sciences
Mycobacterium
Nausea
Pediatrics
Public health
Reviews
Time Factors
Treatment Outcome
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Multidrug-Resistant - drug therapy
Vomiting
Human
Infection
Prognosis
Treatment
Tuberculosis
Multiple resistance
Bacteriosis
Mycobacterial infection
Child
Bibliographic review
ISSN:1473-3099, 1474-4457, 1474-4457
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are based on restricted evidence. We aimed to assess existing evidence for the treatment of MDR tuberculosis in children. We did a systematic review and meta-analysis of published and unpublished studies reporting treatment outcomes for children with MDR tuberculosis. We searched PubMed, Ovid, Embase, Cochrane Library, PsychINFO, and BioMedCentral databases up to Oct 31, 2011. Eligible studies included five or more children (aged ≤16 years) with MDR tuberculosis within a defined treatment cohort. The primary outcome was treatment success, defined as a composite of cure and treatment completion. We identified eight studies, which reported treatment outcomes for a total of 315 patients. We recorded much variation in the characteristics of patients and programmes. Time to appropriate treatment varied from 2 days to 46 months. Average duration of treatment ranged from 6 months to 34 months, and duration of follow-up ranged from 12 months to 37 months. The pooled estimate for treatment success was 81·67% (95% CI 72·54–90·80). Across all studies, 5·9% (95% CI 1·3–10·5) died, 6·2% (2·3–10·2) defaulted, and 39·1% (28·7–49·4) had an adverse event. The most common drug-related adverse events were nausea and vomiting. Other serious adverse events were hearing loss, psychiatric effects, and hypothyroidism. The treatment of paediatric MDR tuberculosis has been neglected, but when children are treated outcomes can be achieved that are at least as good as those reported for adults. Programmes should be encouraged to report outcomes in children to improve the knowledge base for care, especially as new drugs become available. None.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-General Information-1
content type line 14
ObjectType-Feature-3
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Undefined-4
ObjectType-Feature-1
ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(12)70033-6