Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach

•The review provides new information regarding the neurotoxicity mechanisms of herbicides and pesticides.•New perspectives concerning chronic pesticide exposure with amyotrophic lateral sclerosis.•Novel information regarding paraquat exposure and Parkinson's disease.•New insights regarding chro...

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Bibliographic Details
Published in:Toxicology letters Vol. 230; no. 2; pp. 85 - 103
Main Authors: Baltazar, Maria Teresa, Dinis-Oliveira, Ricardo Jorge, de Lourdes Bastos, Maria, Tsatsakis, Aristidis M., Duarte, José Alberto, Carvalho, Félix
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ireland Ltd 15.10.2014
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Animals
Apoptosis - drug effects
Dieldrin - toxicity
Environmental Exposure
Etiology
Exposure
Genesis
Humans
Maneb - toxicity
Neurodegenerative diseases
Neurodegenerative Diseases - chemically induced
Neurological diseases
Organophosphates - toxicity
Oxidative Stress
Paraquat
Paraquat - toxicity
Parkinson Disease, Secondary - chemically induced
Parkinson's disease
Pesticides
Pesticides - toxicity
Proteasome Inhibitors - toxicity
Pyrethrins - toxicity
Risk
Paraquat
Amyotrophic lateral sclerosis
Parkinson's disease
Neurodegenerative diseases
Alzheimer's disease
Pesticides
ISSN:0378-4274, 1879-3169, 1879-3169
Online Access:Get full text
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Summary:•The review provides new information regarding the neurotoxicity mechanisms of herbicides and pesticides.•New perspectives concerning chronic pesticide exposure with amyotrophic lateral sclerosis.•Novel information regarding paraquat exposure and Parkinson's disease.•New insights regarding chronic pesticide exposure and Alzheimer's disease. The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. The role of pesticide exposure in neurodegenerative disease has long been suspected, but the specific causative agents and the mechanisms underlying are not fully understood. For the main neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis there are evidences linking their etiology with long-term/low-dose exposure to pesticides such as paraquat, maneb, dieldrin, pyrethroids and organophosphates. Most of these pesticides share common features, namely the ability to induce oxidative stress, mitochondrial dysfunction, α-synuclein fibrillization and neuronal cell loss. This review aims to clarify the role of pesticides as environmental risk factors in genesis of idiopathic PD and other neurological syndromes. For this purpose, the most relevant epidemiological and experimental data is highlighted in order to discuss the molecular mechanisms involved in neurodegeneration.
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ISSN:0378-4274
1879-3169
1879-3169
DOI:10.1016/j.toxlet.2014.01.039