Leukotriene Production Is Increased in Abdominal Obesity

Obesity is a major risk factor for insulin resistance and type-2 diabetes. A chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis. Results from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induc...

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Vydáno v:PloS one Ročník 9; číslo 12; s. e104593
Hlavní autoři: Bäck, Magnus, Avignon, Antoine, Stanke-Labesque, Françoise, Boegner, Catherine, Attalin, Vincent, Leprieur, Elodie, Sultan, Ariane
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 01.12.2014
Public Library of Science (PLoS)
Témata:
Adolescent
Adult
Aged
Aged, 80 and over
Apnea
Biology and Life Sciences
Blood pressure
Body mass
Body mass index
C-Reactive Protein - metabolism
Cohort Studies
Diabetes mellitus
Female
Females
Glucose tolerance
Hip
Humans
Immunological tolerance
Insulin
Insulin Resistance
Leukotrienes - biosynthesis
Leukotrienes - urine
Male
Medicine and Health Sciences
Middle Aged
Multivariate Analysis
Nutrition
Obesity
Obesity, Abdominal - complications
Obesity, Abdominal - metabolism
Obesity, Abdominal - urine
Research and Analysis Methods
Risk factors
Sleep
Sleep apnea
Sleep Apnea Syndromes - complications
Sleep Apnea Syndromes - metabolism
Sleep disorders
Young Adult
France
ISSN:1932-6203, 1932-6203
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Shrnutí:Obesity is a major risk factor for insulin resistance and type-2 diabetes. A chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis. Results from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induced-insulin resistance. However, there is a paucity of data regarding this association in human obesity. Therefore, the aim of this study was to investigate whether LT production was associated with insulin resistance and other metabolic parameters in a cohort of obese subjects. Forty-six (70% females) obese subjects (BMI≧30 kg/m2) without known diabetes and without inflammatory disease (CRP<10 mg/l) were included. Median age was 44 years (16-80) with a median BMI of 36.8 kg/m2 (30-51). Insulin resistance was evaluated by HOMA-IR index and glucose tolerance test. Urinary LTE4 (U-LTE4) concentration was measured by enzyme immune assay. Screening for obstructive sleep apnea was performed. There was a positive association of U-LTE4 with waist to hip ratio, systolic blood pressure and HOMA-IR in univariate analysis. Further, waist to hip ratio remained the only parameter significantly correlated with U-LTE4, in adjusted multivariate analysis. Taken together, these results confirm the previously established notion of chronic low grade inflammation in obesity and further suggests a role for the LT pathway in obesity-associated development of insulin resistance in humans.
Bibliografie:ObjectType-Article-1
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Conceived and designed the experiments: MB AA AS. Performed the experiments: MB AS. Analyzed the data: MB AS. Wrote the paper: MB AS. Study concept and design: MB AA AS. Patients' inclusion: AA CB VA EL AS. Acquisition of data: MB VA EL CB AA AS. Analysis and interpretation of data: MB AS. Drafting of the manuscript: MB AS. Critical revision of the manuscript for important intellectual content: FSL AA.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0104593