Evaluation of the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment—A systematic review and meta-analysis

This meta-analysis was performed to evaluate the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment. An electronic systematic literature search was conducted in Cochrane Center Register of Controlled Trials, MEDLINE (PubMed) and EmBase in April...

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Vydáno v:Journal of dentistry Ročník 43; číslo 8; s. 913 - 923
Hlavní autoři: Wang, Yining, Gao, Jinxia, Jiang, Tao, Liang, Shanshan, Zhou, Yi, Matis, Bruce A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.08.2015
Elsevier Limited
Témata:
At-home bleaching
Bias
Carbamide peroxide
Chemical products
Clinical trials
Dentin Desensitizing Agents - administration & dosage
Dentistry
Desensitizing
Fluorides
Humans
Hydrogen peroxide
In-office bleaching
Medical Subject Headings-MeSH
Meta-analysis
Nitrates - administration & dosage
Placebos - administration & dosage
Potassium
Potassium Compounds - administration & dosage
Potassium nitrate
Quality
Sodium
Sodium Fluoride - administration & dosage
Studies
Teeth
Tooth bleaching
Tooth Bleaching - methods
Tooth Bleaching Agents - adverse effects
Tooth sensitivity
Treatment Outcome
Tooth bleaching
At-home bleaching
Potassium nitrate
Hydrogen peroxide
Carbamide peroxide
Tooth sensitivity
Desensitizing
In-office bleaching
ISSN:0300-5712, 1879-176X
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Shrnutí:This meta-analysis was performed to evaluate the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment. An electronic systematic literature search was conducted in Cochrane Center Register of Controlled Trials, MEDLINE (PubMed) and EmBase in April, 2014 in English and without time restrictions. Study information extraction and methodological quality assessments were accomplished by two reviewers independently. Methodological quality was assessed by using the “Criteria for judging risk of bias in the ‘Risk of bias’ assessment tool”. Dichotomous data was summarized by odds ratio (OR) with 95% confidence interval (CI) and continuous data was summarized by mean difference (MD) or standardised mean difference (SMD) with 95% confidence interval (CI). Statistical analyses were carried out by using Review Manager 5.2. For evaluation of percent of patients experiencing tooth sensitivity (POTS), the pooled OR of desensitizers vs. placebo was 0.45 (95% CI: 0.28–0.73, P=0.29). The pooled SMD of desensitizers vs. placebo was −0.47 (95% CI: −0.77 to −0.18, P=0.13) in evaluation of level of tooth sensitivity (LOTS). The results of shade evaluation remained inconsistent by evaluating subjective shade guide unit difference (ΔSGU or SGU) and objective colour difference (ΔE). This meta-analysis was performed to evaluate the efficacy of desensitizing agents, potassium nitrate and sodium fluoride, for tooth bleaching treatments. Potassium nitrate and sodium fluoride reduce tooth sensitivity while no consistent conclusion of tooth colour change was found. Tooth sensitivity is a typical side effect associated with tooth bleaching procedures. Potassium nitrate and sodium fluoride are used widely to treat tooth sensitivity. This meta-analysis was performed to evaluate the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment.
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ISSN:0300-5712
1879-176X
DOI:10.1016/j.jdent.2015.03.015