The role of the salience network in cognitive and affective deficits

Analysis and interpretation of studies on cognitive and affective dysregulation often draw upon the network paradigm, especially the Triple Network Model, which consists of the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN). DMN activity is primarily domi...

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Vydáno v:	Frontiers in Human Neuroscience Ročník 17; s. 1133367
Hlavní autoři:	Schimmelpfennig, Jakub, Topczewski, Jan, Zajkowski, Wojciech, Jankowiak-Siuda, Kamila
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Media SA 20.03.2023 Frontiers Media S.A
Témata:	affective dysfunctions cognitive dysfunctions default mode network (DMN) Human Neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 salience network (SN) the frontoparietal network (FPN) triple network model the frontoparietal network (FPN) salience network (SN) affective dysfunctions default mode network (DMN) cognitive dysfunctions triple network model
ISSN:	1662-5161, 1662-5161
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Shrnutí:	Analysis and interpretation of studies on cognitive and affective dysregulation often draw upon the network paradigm, especially the Triple Network Model, which consists of the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN). DMN activity is primarily dominant during cognitive leisure and self-monitoring processes. The FPN peaks during task involvement and cognitive exertion. Meanwhile, the SN serves as a dynamic “switch” between the DMN and FPN, in line with salience and cognitive demand. In the cognitive and affective domains, dysfunctions involving SN activity are connected to a broad spectrum of deficits and maladaptive behavioral patterns in a variety of clinical disorders, such as depression, insomnia, narcissism, PTSD (in the case of SN hyperactivity), chronic pain, and anxiety, high degrees of neuroticism, schizophrenia, epilepsy, autism, and neurodegenerative illnesses, bipolar disorder (in the case of SN hypoactivity). We discuss behavioral and neurological data from various research domains and present an integrated perspective indicating that these conditions can be associated with a widespread disruption in predictive coding at multiple hierarchical levels. We delineate the fundamental ideas of the brain network paradigm and contrast them with the conventional modular method in the first section of this article. Following this, we outline the interaction model of the key functional brain networks and highlight recent studies coupling SN-related dysfunctions with cognitive and affective impairments.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Yaara Yeshurun, Tel Aviv University, Israel Reviewed by: Jean Theberge, St Joseph’s Health Care, Canada Specialty section: This article was submitted to Interacting Minds and Brains, a section of the journal Frontiers in Human Neuroscience
ISSN:	1662-5161 1662-5161
DOI:	10.3389/fnhum.2023.1133367