One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release

In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs- x /3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS)...

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Veröffentlicht in:Nanoscale research letters Jg. 14; H. 1; S. 259 - 12
Hauptverfasser: Wang, Xianshu, Pan, Hongyan, Lin, Qian, Wu, Hong, Jia, Shuangzhu, Shi, Yongyong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Springer US 30.07.2019
Springer Nature B.V
SpringerOpen
Schlagworte:
Adsorption
Biocompatibility
Block copolymers
Carbon
Carbon sources
Carbonization
Chemistry and Materials Science
Chitosan
Contact angle
Drug delivery carrier
Drug delivery systems
Drying
Hydrophilicity
Hydroxycamptothecin
Materials Science
Measuring instruments
Molecular Medicine
Nano Express
Nanochemistry
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Nitrogen
Nitrogen-doped mesoporous carbon spheres
Pore size
Pore size distribution
Porosity
Silicon
Size distribution
Spray drying
Surface chemistry
Tetraethoxysilane
Tetraethyl orthosilicate
X ray photoelectron spectroscopy
Nitrogen-doped mesoporous carbon spheres
Hydroxycamptothecin
Chitosan
Hydrophilicity
Drug delivery carrier
ISSN:1931-7573, 1556-276X
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Zusammenfassung:In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs- x /3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m 2 /g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs- x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs- x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs- x towards HCPT was in the following orders: q NMCs-5/3 > q NMCs-6/3 > q NMCs-7/3 > q NMCs-8/3 . NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g −1 ) and higher dissolution rate (93.75%).
Bibliographie:ObjectType-Article-1
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ISSN:1931-7573
1556-276X
DOI:10.1186/s11671-019-3075-y