Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves’ disease

Purpose The aim of this work was to investigate, in patients with newly diagnosed Graves’ disease (GD), the frequency of islet autoantibodies including autoantibodies against Zink transporter 8 (ZnT8A), as well as to investigate the relation between thyroid autoantibodies, islet autoantibodies and d...

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Veröffentlicht in:Endocrine Jg. 64; H. 1; S. 48 - 54
Hauptverfasser: Jonsdottir, Berglind, Jönsson, Ida, Lantz, Mikael
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Springer US 01.04.2019
Springer Nature B.V
Schlagworte:
Adult
Autoantibodies
Autoantibodies - blood
Autoimmune diseases
Autoimmunity
Beta cells
Clinical Medicine
Comorbidity
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - immunology
Diagnosis
Endocrinology
Endocrinology and Diabetes
Endokrinologi och diabetes
Female
Follow-Up Studies
Glutamate decarboxylase
Glutamate Decarboxylase - immunology
Glutamic acid
Graves Disease - blood
Graves Disease - diagnosis
Graves Disease - epidemiology
Graves Disease - immunology
Graves' disease
Humanities and Social Sciences
Humans
Insulinoma
Internal Medicine
Iodide peroxidase
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original
Original Article
Peroxidase
Prevalence
Science
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Zinc transporter
Zinc Transporter 8 - immunology
Thyroid autoantibodies
Islet autoantibodies
Diabetes
Graves’ disease
ISSN:1355-008X, 1559-0100, 1559-0100
Online-Zugang:Volltext
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Zusammenfassung:Purpose The aim of this work was to investigate, in patients with newly diagnosed Graves’ disease (GD), the frequency of islet autoantibodies including autoantibodies against Zink transporter 8 (ZnT8A), as well as to investigate the relation between thyroid autoantibodies, islet autoantibodies and diabetes both before GD diagnosis and at follow-up. Methods Blood samples from 278 patients with newly diagnosed GD were analyzed for autoantibodies against glutamic acid decarboxylase (GADA), insulinoma-associated protein-2 (IA2-A), three variants of zinc transporter 8 (ZnT8A), thyroid peroxidase (TPOA) and the TSH receptor (TRAb). Information on other autoimmune diseases, as well as development of diabetes during follow up was gathered from patient’s medical journal. Results At GD diagnosis, 13.7% were positive for islet autoantibodies, with the majority being positive for GADA (8.7%) and ZnT8A (7.6%). TPOA were found positive in 71% and TRAb in 83%. No association was found between islet autoantibodies and thyroid autoantibodies or diabetes diagnosis during follow up. Positive association was found between islet autoantibodies and all forms of diabetes, diagnosed both before and after GD (OR: 2.5, CI: 1.1–6.8, p  = 0.03) but not to other autoimmune diseases at GD diagnosis. Conclusions The incidence of GADA and ZnT8A in patients with GD is high and might indicate wide range endocrine autoimmunity, as well as risk for non-autoimmune diabetes rather than exclusively mark beta cell autoimmunity and type 1 diabetes.
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ISSN:1355-008X
1559-0100
1559-0100
DOI:10.1007/s12020-019-01852-w