Lymphatic endothelium in health and disease

The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal absorption of dietary lipids. Substantial progr...

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Vydané v:	Cell and tissue research Ročník 335; číslo 1; s. 97 - 108
Hlavní autori:	Jurisic, Giorgia, Detmar, Michael
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.01.2009 Springer-Verlag Springer Nature B.V
Predmet:	Animals antigen-presenting cells Antigens, Differentiation Antigens, Differentiation - metabolism Biomedical and Life Sciences Biomedicine Cellular biology Development dietary fat Dietary Fats Dietary Fats - metabolism endothelium Endothelium, Lymphatic Endothelium, Lymphatic - metabolism Endothelium, Lymphatic - pathology growth factors homeostasis Human Genetics Humans immune response Immunology inflammation Intercellular Signaling Peptides and Proteins Intercellular Signaling Peptides and Proteins - metabolism Intestinal Absorption lymph nodes Lymph Nodes - metabolism Lymph Nodes - pathology Lymphangiogenesis Lymphatic system Lymphatic Vessels Lymphatic Vessels - metabolism Lymphatic Vessels - pathology Lymphedema Lymphedema - metabolism Lymphedema - pathology Medical research metabolism Molecular biology Molecular Medicine Myocardium Myocardium - metabolism Myocardium - pathology pathology Proteomics Review therapeutics VEGF-C Development Inflammation VEGF-C Lymphedema Lymphangiogenesis
ISSN:	0302-766X, 1432-0878, 1432-0878
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Popis
Shrnutí:	The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal absorption of dietary lipids. Substantial progress in our understanding of the development and the molecular mechanisms controlling the lymphatic system has been made during the last few years, based on a recent wave of discoveries of lymphatic endothelial cell-specific markers and growth factors. This has also led to new insights into the role of lymphatic endothelium in a number of diseases, including primary and secondary lymphedemas. The emerging role of lymphatic endothelium in the context of inflammation indicates that therapeutics targeting the lymphatic vasculature might represent a new strategy for anti-inflammatory therapies.
Bibliografia:	http://dx.doi.org/10.1007/s00441-008-0644-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-3
ISSN:	0302-766X 1432-0878 1432-0878
DOI:	10.1007/s00441-008-0644-2