Lymphatic endothelium in health and disease

The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal absorption of dietary lipids. Substantial progr...

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Veröffentlicht in:Cell and tissue research Jg. 335; H. 1; S. 97 - 108
Hauptverfasser: Jurisic, Giorgia, Detmar, Michael
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.01.2009
Springer-Verlag
Springer Nature B.V
Schlagworte:
Animals
antigen-presenting cells
Antigens, Differentiation
Antigens, Differentiation - metabolism
Biomedical and Life Sciences
Biomedicine
Cellular biology
Development
dietary fat
Dietary Fats
Dietary Fats - metabolism
endothelium
Endothelium, Lymphatic
Endothelium, Lymphatic - metabolism
Endothelium, Lymphatic - pathology
growth factors
homeostasis
Human Genetics
Humans
immune response
Immunology
inflammation
Intercellular Signaling Peptides and Proteins
Intercellular Signaling Peptides and Proteins - metabolism
Intestinal Absorption
lymph nodes
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphangiogenesis
Lymphatic system
Lymphatic Vessels
Lymphatic Vessels - metabolism
Lymphatic Vessels - pathology
Lymphedema
Lymphedema - metabolism
Lymphedema - pathology
Medical research
metabolism
Molecular biology
Molecular Medicine
Myocardium
Myocardium - metabolism
Myocardium - pathology
pathology
Proteomics
Review
therapeutics
VEGF-C
Development
Inflammation
VEGF-C
Lymphedema
Lymphangiogenesis
ISSN:0302-766X, 1432-0878, 1432-0878
Online-Zugang:Volltext
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Zusammenfassung:The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal absorption of dietary lipids. Substantial progress in our understanding of the development and the molecular mechanisms controlling the lymphatic system has been made during the last few years, based on a recent wave of discoveries of lymphatic endothelial cell-specific markers and growth factors. This has also led to new insights into the role of lymphatic endothelium in a number of diseases, including primary and secondary lymphedemas. The emerging role of lymphatic endothelium in the context of inflammation indicates that therapeutics targeting the lymphatic vasculature might represent a new strategy for anti-inflammatory therapies.
Bibliographie:http://dx.doi.org/10.1007/s00441-008-0644-2
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ISSN:0302-766X
1432-0878
1432-0878
DOI:10.1007/s00441-008-0644-2