Multidisciplinary model to implement pharmacogenomics at the point of care

Despite potential clinical benefits, implementation of pharmacogenomics (PGx) faces many technical and clinical challenges. These challenges can be overcome with a comprehensive and systematic implementation model. The development and implementation of PGx were organized into eight interdependent co...

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Vydané v:Genetics in medicine Ročník 19; číslo 4; s. 421 - 429
Hlavní autori: Caraballo, Pedro J., Hodge, Lucy S., Bielinski, Suzette J., Stewart, A. Keith, Farrugia, Gianrico, Schultz, Cloann G., Rohrer-Vitek, Carolyn R., Olson, Janet E., St. Sauver, Jennifer L., Roger, Veronique L., Parkulo, Mark A., Kullo, Iftikhar J., Nicholson, Wayne T., Elliott, Michelle A., Black, John L., Weinshilboum, Richard M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Elsevier Inc 01.04.2017
Nature Publishing Group US
Elsevier Limited
Predmet:
631/208/1516
631/208/212/1728
631/208/212/2166
Biomedicine
clinical decision support systems
Decision Support Systems, Clinical
delivery of health care
Delivery of Health Care, Integrated - methods
Electronic Health Records
Human Genetics
Humans
Laboratory Medicine
medical informatics
Models, Theoretical
original-research-article
pharmacogenetics
Pharmacogenetics - education
Point-of-Care Systems
Precision Medicine
precision medicine
medical informatics
clinical decision support systems
delivery of health care
pharmacogenetics
ISSN:1098-3600, 1530-0366
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Shrnutí:Despite potential clinical benefits, implementation of pharmacogenomics (PGx) faces many technical and clinical challenges. These challenges can be overcome with a comprehensive and systematic implementation model. The development and implementation of PGx were organized into eight interdependent components addressing resources, governance, clinical practice, education, testing, knowledge translation, clinical decision support (CDS), and maintenance. Several aspects of implementation were assessed, including adherence to the model, production of PGx-CDS interventions, and access to educational resources. Between August 2012 and June 2015, 21 specific drug–gene interactions were reviewed and 18 of them were implemented in the electronic medical record as PGx-CDS interventions. There was complete adherence to the model with variable production time (98–392 days) and delay time (0–148 days). The implementation impacted approximately 1,247 unique providers and 3,788 unique patients. A total of 11 educational resources complementary to the drug–gene interactions and 5 modules specific for pharmacists were developed and implemented. A comprehensive operational model can support PGx implementation in routine prescribing. Institutions can use this model as a roadmap to support similar efforts. However, we also identified challenges that will require major multidisciplinary and multi-institutional efforts to make PGx a universal reality. Genet Med19 4, 421–429.
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ISSN:1098-3600
1530-0366
DOI:10.1038/gim.2016.120