Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis

Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This s...

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Vydané v:	BMC neurology Ročník 13; číslo 1; s. 37
Hlavní autori:	Learmonth, Yvonne C, Motl, Robert W, Sandroff, Brian M, Pula, John H, Cadavid, Diego
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 25.04.2013 BioMed Central Ltd Springer Nature B.V
Predmet:	Adult Aged Care and treatment Demyelinating diseases Disability Evaluation Exercise Test Female Humans Male Medicine Medicine & Public Health Middle Aged Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - physiopathology Neurochemistry Neurology Neuropsychological Tests Neurosurgery Patient Outcome Assessment Quality of life Reproducibility of Results Research Article Severity of Illness Index Studies Validity Walking United States Multiple Sclerosis Pace Auditory Serial Additional Test Expand Disability Status Scale Score Symbol Digit Modality Test Expand Disability Status Scale
ISSN:	1471-2377, 1471-2377
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Popis
Shrnutí:	Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. Methods 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. Results There was a strong correlation between EDSS and PDDS scores ( ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal ( ρ = .578 & ρ = .647, respectively) and Cerebellar ( ρ = .501 & ρ = .528, respectively) FS scores as well as 6 MW distance ( ρ = .704 & ρ = .805, respectively), MSWS-12 scores ( ρ = .801 & ρ = .729, respectively), and accelerometer steps/day ( ρ = -.740 & ρ = -.717, respectively). Conclusion This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2377 1471-2377
DOI:	10.1186/1471-2377-13-37