Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress

DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress during replication. The activity of the SMC complex...

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Veröffentlicht in:	Molecular cell Jg. 78; H. 4; S. 739
Hauptverfasser:	Minchell, Nicola Elizabeth, Keszthelyi, Andrea, Baxter, Jonathan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.05.2020
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomes, Fungal Cohesins DNA Damage DNA Replication DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism DNA, Fungal - genetics DNA, Fungal - metabolism DNA, Ribosomal - genetics DNA, Ribosomal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism DNA topology cohesin condensin DNA damage SMC topoisomerases DNA replication stress
ISSN:	1097-4164, 1097-4164
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