Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular membranes, and regulate energy metabolism. Questions remain as to which lipid species maintain metabolic homeostasis and which disrupt essential cellular functions, leading to metabolic disorders. He...

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Bibliographic Details
Published in:Molecular cell Vol. 81; no. 18; p. 3708
Main Authors: Yoon, Haejin, Shaw, Jillian L, Haigis, Marcia C, Greka, Anna
Format: Journal Article
Language:English
Published: United States 16.09.2021
Subjects:
Animals
Chromatin - metabolism
Disease
Energy Metabolism - physiology
Health
Homeostasis - physiology
Humans
Immunity - physiology
Lipid Metabolism - physiology
Lipidomics - methods
Lipids - physiology
Metabolic Diseases - metabolism
Metabolic Diseases - physiopathology
Metabolomics - methods
Microbiota - physiology
Signal Transduction - physiology
free fatty acids (FFAs)
lipids
triacylglycerol accumulation
cellular metabolism
lipid metabolism
lipotoxicity
cancer
lipidomics
obesity
ISSN:1097-4164, 1097-4164
Online Access:Get more information
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Summary:Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular membranes, and regulate energy metabolism. Questions remain as to which lipid species maintain metabolic homeostasis and which disrupt essential cellular functions, leading to metabolic disorders. Here, we discuss recent advances in understanding lipid metabolism with a focus on catabolism, synthesis, and signaling. Technical advances, including functional genomics, metabolomics, lipidomics, lipid-protein interaction maps, and advances in mass spectrometry, have uncovered new ways to prioritize molecular mechanisms mediating lipid function. By reviewing what is known about the distinct effects of specific lipid species in physiological pathways, we provide a framework for understanding newly identified targets regulating lipid homeostasis with implications for ameliorating metabolic diseases.
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ISSN:1097-4164
1097-4164
DOI:10.1016/j.molcel.2021.08.027