Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1

The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD. HK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived e...

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Vydané v:	Renal failure Ročník 45; číslo 1; s. 2177082
Hlavní autori:	Lv, Jia, Hao, Ya-Ning, Wang, Xiao-Pei, Lu, Wan-Hong, Xie, Li-Yi, Niu, Dan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis 01.12.2023 Taylor & Francis Ltd Taylor & Francis Group
Predmet:	Bone marrow bone marrow mesenchymal stem cells Caspase-1 Caspases - metabolism Caspases - pharmacology Cell Line Clinical Study Cytotoxicity Diabetes mellitus diabetic kidney disease ELAV-Like Protein 1 - genetics Enzyme-linked immunosorbent assay exosome Exosomes Flow cytometry Glucose - metabolism Glucose - pharmacology Humans IL-1β Interleukin 18 Interleukin-18 - metabolism Interleukin-18 - pharmacology Kidney diseases Kidney Tubules, Proximal - cytology L-Lactate dehydrogenase Mesenchymal stem cells Mesenchymal Stem Cells - metabolism MicroRNAs - genetics miR-30e-5p Overexpression Pyroptosis Reporter gene RNA-binding protein diabetic kidney disease Pyroptosis bone marrow mesenchymal stem cells exosome miR-30e-5p
ISSN:	0886-022X, 1525-6049, 1525-6049
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Abstract	The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD. HK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived exosomes (BMSC-exos) were isolated and internalized into HK-2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays were used to measure viability and cytotoxicity. The secretion of IL-1β and IL-18 was measured by ELISA. Pyroptosis was assessed by flow cytometry. Quantitative RT-PCR was used to measure the levels of miR-30e-5p, ELAV like RNA binding protein 1 (ELAVL1), IL-1β, and IL-18. The expression of ELAVL1 and pyroptosis-associated cytokine proteins was determined by western blot analysis. A dual-luciferase reporter gene assay was conducted to confirm the relationship between miR-30e-5p and ELAVL1. BMSC-exos decreased LDH, IL-1β, and IL-18 secretion and inhibited the expression of the pyroptosis-related factors (IL-1β, caspase-1, GSDMD-N, and NLRP3) in HG-induced HK-2 cells. Moreover, miR-30e-5p depletion derived from BMSC-exos promoted HK-2 cell pyroptosis. Besides, miR-30e-5p over-expression or ELVAL1 knockdown could directly inhibit pyroptosis. ELAVL1 was a target of miR-30e-5p and knocking down ELAVL1 reversed the effect of miR-30e-5p inhibition in BMSC-exos-treated HK-2 cells. BMSC-derived exosomal miR-30e-5p inhibits caspase-1-mediated pyroptosis by targeting ELAVL1 in HG-induced HK-2 cells, which might provide a new strategy for treating DKD.
AbstractList	BackgroundThe rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD.MethodsHK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived exosomes (BMSC-exos) were isolated and internalized into HK-2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays were used to measure viability and cytotoxicity. The secretion of IL-1β and IL-18 was measured by ELISA. Pyroptosis was assessed by flow cytometry. Quantitative RT-PCR was used to measure the levels of miR-30e-5p, ELAV like RNA binding protein 1 (ELAVL1), IL-1β, and IL-18. The expression of ELAVL1 and pyroptosis-associated cytokine proteins was determined by western blot analysis. A dual-luciferase reporter gene assay was conducted to confirm the relationship between miR-30e-5p and ELAVL1.ResultsBMSC-exos decreased LDH, IL-1β, and IL-18 secretion and inhibited the expression of the pyroptosis-related factors (IL-1β, caspase-1, GSDMD-N, and NLRP3) in HG-induced HK-2 cells. Moreover, miR-30e-5p depletion derived from BMSC-exos promoted HK-2 cell pyroptosis. Besides, miR-30e-5p over-expression or ELVAL1 knockdown could directly inhibit pyroptosis. ELAVL1 was a target of miR-30e-5p and knocking down ELAVL1 reversed the effect of miR-30e-5p inhibition in BMSC-exos-treated HK-2 cells.ConclusionsBMSC-derived exosomal miR-30e-5p inhibits caspase-1-mediated pyroptosis by targeting ELAVL1 in HG-induced HK-2 cells, which might provide a new strategy for treating DKD. The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD.BACKGROUNDThe rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD.HK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived exosomes (BMSC-exos) were isolated and internalized into HK-2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays were used to measure viability and cytotoxicity. The secretion of IL-1β and IL-18 was measured by ELISA. Pyroptosis was assessed by flow cytometry. Quantitative RT-PCR was used to measure the levels of miR-30e-5p, ELAV like RNA binding protein 1 (ELAVL1), IL-1β, and IL-18. The expression of ELAVL1 and pyroptosis-associated cytokine proteins was determined by western blot analysis. A dual-luciferase reporter gene assay was conducted to confirm the relationship between miR-30e-5p and ELAVL1.METHODSHK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived exosomes (BMSC-exos) were isolated and internalized into HK-2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays were used to measure viability and cytotoxicity. The secretion of IL-1β and IL-18 was measured by ELISA. Pyroptosis was assessed by flow cytometry. Quantitative RT-PCR was used to measure the levels of miR-30e-5p, ELAV like RNA binding protein 1 (ELAVL1), IL-1β, and IL-18. The expression of ELAVL1 and pyroptosis-associated cytokine proteins was determined by western blot analysis. A dual-luciferase reporter gene assay was conducted to confirm the relationship between miR-30e-5p and ELAVL1.BMSC-exos decreased LDH, IL-1β, and IL-18 secretion and inhibited the expression of the pyroptosis-related factors (IL-1β, caspase-1, GSDMD-N, and NLRP3) in HG-induced HK-2 cells. Moreover, miR-30e-5p depletion derived from BMSC-exos promoted HK-2 cell pyroptosis. Besides, miR-30e-5p over-expression or ELVAL1 knockdown could directly inhibit pyroptosis. ELAVL1 was a target of miR-30e-5p and knocking down ELAVL1 reversed the effect of miR-30e-5p inhibition in BMSC-exos-treated HK-2 cells.RESULTSBMSC-exos decreased LDH, IL-1β, and IL-18 secretion and inhibited the expression of the pyroptosis-related factors (IL-1β, caspase-1, GSDMD-N, and NLRP3) in HG-induced HK-2 cells. Moreover, miR-30e-5p depletion derived from BMSC-exos promoted HK-2 cell pyroptosis. Besides, miR-30e-5p over-expression or ELVAL1 knockdown could directly inhibit pyroptosis. ELAVL1 was a target of miR-30e-5p and knocking down ELAVL1 reversed the effect of miR-30e-5p inhibition in BMSC-exos-treated HK-2 cells.BMSC-derived exosomal miR-30e-5p inhibits caspase-1-mediated pyroptosis by targeting ELAVL1 in HG-induced HK-2 cells, which might provide a new strategy for treating DKD.CONCLUSIONSBMSC-derived exosomal miR-30e-5p inhibits caspase-1-mediated pyroptosis by targeting ELAVL1 in HG-induced HK-2 cells, which might provide a new strategy for treating DKD. The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD. HK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived exosomes (BMSC-exos) were isolated and internalized into HK-2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays were used to measure viability and cytotoxicity. The secretion of IL-1β and IL-18 was measured by ELISA. Pyroptosis was assessed by flow cytometry. Quantitative RT-PCR was used to measure the levels of miR-30e-5p, ELAV like RNA binding protein 1 (ELAVL1), IL-1β, and IL-18. The expression of ELAVL1 and pyroptosis-associated cytokine proteins was determined by western blot analysis. A dual-luciferase reporter gene assay was conducted to confirm the relationship between miR-30e-5p and ELAVL1. BMSC-exos decreased LDH, IL-1β, and IL-18 secretion and inhibited the expression of the pyroptosis-related factors (IL-1β, caspase-1, GSDMD-N, and NLRP3) in HG-induced HK-2 cells. Moreover, miR-30e-5p depletion derived from BMSC-exos promoted HK-2 cell pyroptosis. Besides, miR-30e-5p over-expression or ELVAL1 knockdown could directly inhibit pyroptosis. ELAVL1 was a target of miR-30e-5p and knocking down ELAVL1 reversed the effect of miR-30e-5p inhibition in BMSC-exos-treated HK-2 cells. BMSC-derived exosomal miR-30e-5p inhibits caspase-1-mediated pyroptosis by targeting ELAVL1 in HG-induced HK-2 cells, which might provide a new strategy for treating DKD. Background The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD.Methods HK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived exosomes (BMSC-exos) were isolated and internalized into HK-2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays were used to measure viability and cytotoxicity. The secretion of IL-1β and IL-18 was measured by ELISA. Pyroptosis was assessed by flow cytometry. Quantitative RT-PCR was used to measure the levels of miR-30e-5p, ELAV like RNA binding protein 1 (ELAVL1), IL-1β, and IL-18. The expression of ELAVL1 and pyroptosis-associated cytokine proteins was determined by western blot analysis. A dual-luciferase reporter gene assay was conducted to confirm the relationship between miR-30e-5p and ELAVL1.Results BMSC-exos decreased LDH, IL-1β, and IL-18 secretion and inhibited the expression of the pyroptosis-related factors (IL-1β, caspase-1, GSDMD-N, and NLRP3) in HG-induced HK-2 cells. Moreover, miR-30e-5p depletion derived from BMSC-exos promoted HK-2 cell pyroptosis. Besides, miR-30e-5p over-expression or ELVAL1 knockdown could directly inhibit pyroptosis. ELAVL1 was a target of miR-30e-5p and knocking down ELAVL1 reversed the effect of miR-30e-5p inhibition in BMSC-exos-treated HK-2 cells.Conclusions BMSC-derived exosomal miR-30e-5p inhibits caspase-1-mediated pyroptosis by targeting ELAVL1 in HG-induced HK-2 cells, which might provide a new strategy for treating DKD.
Author	Hao, Ya-Ning Lu, Wan-Hong Xie, Li-Yi Lv, Jia Wang, Xiao-Pei Niu, Dan
Author_xml	– sequence: 1 givenname: Jia surname: Lv fullname: Lv, Jia organization: Department of Nephrology, College of Medicine, Nephrotic Hospital, First Affiliated Hospital, Xi'an Jiaotong University – sequence: 2 givenname: Ya-Ning surname: Hao fullname: Hao, Ya-Ning organization: Department of Nephrology, College of Medicine, Nephrotic Hospital, First Affiliated Hospital, Xi'an Jiaotong University – sequence: 3 givenname: Xiao-Pei surname: Wang fullname: Wang, Xiao-Pei organization: Department of Nephrology, College of Medicine, Nephrotic Hospital, First Affiliated Hospital, Xi'an Jiaotong University – sequence: 4 givenname: Wan-Hong surname: Lu fullname: Lu, Wan-Hong organization: Department of Nephrology, College of Medicine, Nephrotic Hospital, First Affiliated Hospital, Xi'an Jiaotong University – sequence: 5 givenname: Li-Yi surname: Xie fullname: Xie, Li-Yi organization: Department of Nephrology, College of Medicine, Nephrotic Hospital, First Affiliated Hospital, Xi'an Jiaotong University – sequence: 6 givenname: Dan surname: Niu fullname: Niu, Dan organization: Department of Nephrology, College of Medicine, Nephrotic Hospital, First Affiliated Hospital, Xi'an Jiaotong University
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Cites_doi	10.1016/j.canlet.2014.10.006 10.1007/s13770-017-0026-5 10.1186/s13287-022-03071-z 10.1016/j.yexcr.2019.06.008 10.3892/or.2017.5683 10.1002/ijc.30854 10.1186/s13287-020-01852-y 10.1073/pnas.0608249103 10.3390/cells7120226 10.1155/2019/2923072 10.1016/j.biopha.2019.109613 10.1016/j.cca.2021.09.003 10.1152/ajprenal.00533.2014 10.1002/tox.23553 10.1038/cdd.2011.37 10.1016/j.diabres.2014.01.011 10.1016/j.molmet.2020.02.011 10.3389/fcell.2019.00379 10.1155/2015/697010 10.1038/nrmicro2070 10.1186/s13287-018-0791-7 10.1038/nrneph.2015.173 10.1016/j.ejphar.2021.174121 10.3390/ijms21197057 10.1038/s41418-018-0212-6 10.1111/cas.14563 10.3390/ijms14035338 10.1155/2019/6935806 10.1186/s12902-022-00968-x 10.1186/s12967-018-1486-7 10.1371/journal.pone.0150154 10.3389/fimmu.2022.835879 10.1177/0963689720904628 10.1038/nri2567 10.1038/s41598-019-40163-y 10.1016/j.yexcr.2016.12.006 10.1590/2175-8239-jbn-2018-0165 10.1002/jcp.26959 10.1186/s12929-022-00814-1 10.1038/s12276-019-0279-2 10.1152/ajprenal.00387.2015
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Keywords	diabetic kidney disease Pyroptosis bone marrow mesenchymal stem cells exosome miR-30e-5p
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References_xml	– ident: e_1_3_4_15_1 doi: 10.1016/j.canlet.2014.10.006 – ident: e_1_3_4_5_1 doi: 10.1007/s13770-017-0026-5 – ident: e_1_3_4_27_1 doi: 10.1186/s13287-022-03071-z – ident: e_1_3_4_43_1 doi: 10.1016/j.yexcr.2019.06.008 – ident: e_1_3_4_16_1 doi: 10.3892/or.2017.5683 – ident: e_1_3_4_17_1 doi: 10.1002/ijc.30854 – ident: e_1_3_4_34_1 doi: 10.1186/s13287-020-01852-y – ident: e_1_3_4_31_1 doi: 10.1073/pnas.0608249103 – ident: e_1_3_4_4_1 doi: 10.3390/cells7120226 – ident: e_1_3_4_25_1 doi: 10.1155/2019/2923072 – ident: e_1_3_4_36_1 doi: 10.1016/j.biopha.2019.109613 – ident: e_1_3_4_37_1 doi: 10.1016/j.cca.2021.09.003 – ident: e_1_3_4_45_1 doi: 10.1152/ajprenal.00533.2014 – ident: e_1_3_4_40_1 doi: 10.1002/tox.23553 – ident: e_1_3_4_20_1 doi: 10.1038/cdd.2011.37 – ident: e_1_3_4_32_1 doi: 10.1016/j.diabres.2014.01.011 – ident: e_1_3_4_24_1 doi: 10.1016/j.molmet.2020.02.011 – ident: e_1_3_4_26_1 doi: 10.3389/fcell.2019.00379 – volume: 18 start-page: 2574 issue: 4 year: 2019 ident: e_1_3_4_7_1 article-title: Bone marrow mesenchymal stem cell-derived exosomes protect against myocardial infarction by promoting autophagy publication-title: Exp Ther Med – ident: e_1_3_4_3_1 doi: 10.1155/2015/697010 – ident: e_1_3_4_21_1 doi: 10.1038/nrmicro2070 – ident: e_1_3_4_6_1 doi: 10.1186/s13287-018-0791-7 – ident: e_1_3_4_29_1 doi: 10.1038/nrneph.2015.173 – volume: 47 start-page: 397 issue: 4 year: 2009 ident: e_1_3_4_2_1 article-title: Risk factors for diabetic nephropathy: intrinsic or extrinsic renal? publication-title: Rom J Intern Med – ident: e_1_3_4_44_1 doi: 10.1016/j.ejphar.2021.174121 – ident: e_1_3_4_38_1 doi: 10.3390/ijms21197057 – ident: e_1_3_4_22_1 doi: 10.1038/s41418-018-0212-6 – volume: 122 start-page: 2573 issue: 21 year: 2009 ident: e_1_3_4_33_1 article-title: Mesenchymal stem cells transplantation mildly ameliorates experimental diabetic nephropathy in rats publication-title: Chin Med J – ident: e_1_3_4_10_1 doi: 10.1111/cas.14563 – ident: e_1_3_4_12_1 doi: 10.3390/ijms14035338 – ident: e_1_3_4_28_1 doi: 10.1155/2019/6935806 – ident: e_1_3_4_39_1 doi: 10.1186/s12902-022-00968-x – ident: e_1_3_4_18_1 doi: 10.1186/s12967-018-1486-7 – ident: e_1_3_4_19_1 doi: 10.1371/journal.pone.0150154 – ident: e_1_3_4_42_1 doi: 10.3389/fimmu.2022.835879 – ident: e_1_3_4_8_1 doi: 10.1177/0963689720904628 – ident: e_1_3_4_11_1 doi: 10.1038/nri2567 – ident: e_1_3_4_30_1 doi: 10.1038/s41598-019-40163-y – ident: e_1_3_4_23_1 doi: 10.1016/j.yexcr.2016.12.006 – ident: e_1_3_4_14_1 doi: 10.1590/2175-8239-jbn-2018-0165 – ident: e_1_3_4_35_1 doi: 10.1002/jcp.26959 – ident: e_1_3_4_41_1 doi: 10.1186/s12929-022-00814-1 – ident: e_1_3_4_9_1 doi: 10.1038/s12276-019-0279-2 – ident: e_1_3_4_13_1 doi: 10.1152/ajprenal.00387.2015
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Snippet	The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells... BackgroundThe rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal... Background The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal...
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SubjectTerms	Bone marrow bone marrow mesenchymal stem cells Caspase-1 Caspases - metabolism Caspases - pharmacology Cell Line Clinical Study Cytotoxicity Diabetes mellitus diabetic kidney disease ELAV-Like Protein 1 - genetics Enzyme-linked immunosorbent assay exosome Exosomes Flow cytometry Glucose - metabolism Glucose - pharmacology Humans IL-1β Interleukin 18 Interleukin-18 - metabolism Interleukin-18 - pharmacology Kidney diseases Kidney Tubules, Proximal - cytology L-Lactate dehydrogenase Mesenchymal stem cells Mesenchymal Stem Cells - metabolism MicroRNAs - genetics miR-30e-5p Overexpression Pyroptosis Reporter gene RNA-binding protein
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Title	Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1
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