Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction

Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power a plethora of functions requiring organization and restructuring of eukaryotic chromosomes in interphase and during mitosis. The Smc5/6 mechanism of action and its activity on DNA are largely unknown. Here we purif...

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Veröffentlicht in:	Molecular cell Jg. 80; H. 6; S. 1039
Hauptverfasser:	Gutierrez-Escribano, Pilar, Hormeño, Silvia, Madariaga-Marcos, Julene, Solé-Soler, Roger, O'Reilly, Francis J, Morris, Kyle, Aicart-Ramos, Clara, Aramayo, Ricardo, Montoya, Alex, Kramer, Holger, Rappsilber, Juri, Torres-Rosell, Jordi, Moreno-Herrero, Fernando, Aragon, Luis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.12.2020
Schlagworte:	Adenosine Triphosphatases - genetics Biophysical Phenomena Cell Cycle Proteins - genetics Cell Cycle Proteins - ultrastructure Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - ultrastructure Cohesins DNA-Binding Proteins - genetics Humans Interphase - genetics Mitosis - genetics Multiprotein Complexes - genetics Multiprotein Complexes - ultrastructure Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - ultrastructure Sumoylation - genetics electron mmicroscopy single-molecule magnetic tweezers Smc5/6 holocomplex plectoneme stabilisation Smc5/6 purification DNA compaction DNA substrate recognition
ISSN:	1097-4164, 1097-4164
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