Mitovirus and Mitochondrial Coding Sequences from Basal Fungus Entomophthora muscae

Fungi constituting the Entomophthora muscae species complex (members of subphylum Entomophthoromycotina, phylum Zoopagamycota) commonly kill their insect hosts and manipulate host behaviors in the process. In this study, we made use of public transcriptome data to identify and characterize eight new...

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Bibliographic Details
Published in:Viruses Vol. 11; no. 4; p. 351
Main Authors: Nibert, Max, Debat, Humberto, Manny, Austin, Grigoriev, Igor, De Fine Licht, Henrik
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 17.04.2019
MDPI
Subjects:
BASIC BIOLOGICAL SCIENCES
Bioinformatics
Cell division
Codon
Codons
database mining
Databases, Genetic
Entomophthora
Entomophthora - classification
Entomophthora - genetics
Entomophthora - virology
Entomophthora muscae
Entomophthoromycotina
Evolution, Molecular
Exons
fungal virus
Fungal Viruses - classification
Fungal Viruses - genetics
Fungi
Gene expression
Genomes
Mitochondria
Mitochondria - genetics
Mitochondria - virology
Mitochondrial Proteins - genetics
mitochondrion
Mitovirus
mycovirus
Narnaviridae
New species
Phylogenetics
Phylogeny
RNA polymerase
RNA viruses
RNA Viruses - classification
RNA Viruses - genetics
Transcriptome
Transcriptomes
virus discovery
United States > US
database mining
mycovirus
fungal virus
Entomophthora
Narnaviridae
Entomophthoromycotina
virus discovery
Mitovirus
mitochondrion
ISSN:1999-4915, 1999-4915
Online Access:Get full text
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Summary:Fungi constituting the Entomophthora muscae species complex (members of subphylum Entomophthoromycotina, phylum Zoopagamycota) commonly kill their insect hosts and manipulate host behaviors in the process. In this study, we made use of public transcriptome data to identify and characterize eight new species of mitoviruses associated with several different E. muscae isolates. Mitoviruses are simple RNA viruses that replicate in host mitochondria and are frequently found in more phylogenetically apical fungi (members of subphylum Glomeromyoctina, phylum Mucoromycota, phylum Basidiomycota and phylum Ascomycota) as well as in plants. E. muscae is the first fungus from phylum Zoopagomycota, and thereby the most phylogenetically basal fungus, found to harbor mitoviruses to date. Multiple UGA (Trp) codons are found not only in each of the new mitovirus sequences from E. muscae but also in mitochondrial core-gene coding sequences newly assembled from E. muscae transcriptome data, suggesting that UGA (Trp) is not a rarely used codon in the mitochondria of this fungus. The presence of mitoviruses in these basal fungi has possible implications for the evolution of these viruses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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AC02-05CH11231
USDOE Office of Science (SC)
National Institutes of Health (NIH)
ISSN:1999-4915
1999-4915
DOI:10.3390/v11040351