Human, animal and environmental contributors to antibiotic resistance in low-resource settings: integrating behavioural, epidemiological and One Health approaches

Antibiotic resistance (ABR) is recognized as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals...

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Bibliographic Details
Published in:Proceedings of the Royal Society. B, Biological sciences Vol. 285; no. 1876
Main Authors: Rousham, Emily K, Unicomb, Leanne, Islam, Mohammad Aminul
Format: Journal Article
Language:English
Published: England 11.04.2018
Subjects:
Animal Husbandry - methods
Animals
Anti-Bacterial Agents
Developing Countries
Drug Resistance, Bacterial
Ecosystem
Enterobacteriaceae - genetics
Enterobacteriaceae Infections - transmission
Food Microbiology
Humans
One Health
Risk Factors
drug-resistant bacteria
low- and middle-income countries
One Health
ISSN:1471-2954, 1471-2954
Online Access:Get more information
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Summary:Antibiotic resistance (ABR) is recognized as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals and the environment in low-resource settings. This critical review seeks to identify the extent of One Health research on ABR in low- and middle-income countries (LMICs). Existing research has highlighted hotspots for environmental contamination; food-animal production systems that are likely to harbour reservoirs or promote transmission of ABR as well as high and increasing human rates of colonization with ABR commensal bacteria such as However, very few studies have integrated all three components of the One Health spectrum to understand the dynamics of transmission and the prevalence of community-acquired resistance in humans and animals. Microbiological, epidemiological and social science research is needed at community and population levels across the One Health spectrum in order to fill the large gaps in knowledge of ABR in low-resource settings.
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ISSN:1471-2954
1471-2954
DOI:10.1098/rspb.2018.0332