Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China

Enterovirus 76 (EV-A76) is a serotype of enterovirus A and has been rarely reported. In this paper, we present the genetic characteristics of 15 EV-A76 isolates reported to circulate in the Xinjiang Uighur autonomous region of China in 2011. Sequence analysis revealed that all Chinese EV-A76 isolate...

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Bibliographic Details
Published in:Emerging microbes & infections Vol. 12; no. 1; p. 2149350
Main Authors: Li, Xiaolei, Lu, Huanhuan, Sun, Qiang, Zheng, Peng, Zhang, Bo, Cui, Hui, Tang, Haishu, Zhao, Hehe, Liu, Ying, Jiang, Jie, Xiao, Jinbo, Zhang, Yong
Format: Journal Article
Language:English
Published: United States Taylor & Francis 01.12.2023
Taylor & Francis Ltd
Taylor & Francis Group
Subjects:
Antigens, Viral - genetics
China - epidemiology
Enterovirus
Enterovirus A76
Enterovirus Infections
Genome, Viral
Humans
Letter
Nucleotides
Phylogeny
recombination
transmission
China
recombination
transmission
Enterovirus A76
ISSN:2222-1751, 2222-1751
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Summary:Enterovirus 76 (EV-A76) is a serotype of enterovirus A and has been rarely reported. In this paper, we present the genetic characteristics of 15 EV-A76 isolates reported to circulate in the Xinjiang Uighur autonomous region of China in 2011. Sequence analysis revealed that all Chinese EV-A76 isolates had high similarity (> 98.3%) in the VP1 region, and five Chinese EV-A76 isolates were selected for whole genome sequencing based on VP1 nucleotide divergence. Similarity plots and boot-scanning analyses revealed frequent intertypic recombination in the nonstructural region of the EV-A76 isolate, as found with the EV-A89 donor sequence (also isolated in Xinjiang). The breakpoint of recombination is around nucleotide 3960, and the recombinant fragments covered part 2C and all P3 regions. This study increases publicly available EV-A76 nucleotide sequence and further our understanding EV-A76 molecular epidemiology.
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Supplemental data for this article can be accessed online at https://doi.org/10.1080/22221751.2022.2149350
These authors contribute equally to this manuscript.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2022.2149350