Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules from their parent cells, EVs are important mediators of intercellular communication and thus play significant roles in ph...

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Vydáno v:Drug delivery Ročník 27; číslo 1; s. 585 - 598
Hlavní autoři: Meng, Wanrong, He, Chuanshi, Hao, Yaying, Wang, Linlin, Li, Ling, Zhu, Guiquan
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Taylor & Francis 01.01.2020
Taylor & Francis Ltd
Taylor & Francis Group
Témata:
Biocompatibility
Biosynthesis
Cancer therapies
CRISPR
Drug Carriers - metabolism
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
exosomes
Extracellular Vesicles
Humans
Laboratories
Ligands
microvesicles
Nanoparticles
Proteins
Drug delivery
extracellular vesicles
microvesicles
exosomes
ISSN:1071-7544, 1521-0464, 1521-0464
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Shrnutí:Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules from their parent cells, EVs are important mediators of intercellular communication and thus play significant roles in physiological and pathological processes. Owing to their natural biogenesis process, EVs are generated with high biocompatibility, enhanced stability, and limited immunogenicity, which provide multiple advantages as drug delivery systems (DDSs) over traditional synthetic delivery vehicles. EVs have been reported to be used for the delivery of siRNAs, miRNAs, protein, small molecule drugs, nanoparticles, and CRISPR/Cas9 in the treatment of various diseases. As a natural drug delivery vectors, EVs can penetrate into the tissues and be bioengineered to enhance the targetability. Although EVs' characteristics make them ideal for drug delivery, EV-based drug delivery remains challenging, due to lack of standardized isolation and purification methods, limited drug loading efficiency, and insufficient clinical grade production. In this review, we summarized the current knowledge on the application of EVs as DDS from the perspective of different cell origin and weighted the advantages and bottlenecks of EV-based DDS.
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ISSN:1071-7544
1521-0464
1521-0464
DOI:10.1080/10717544.2020.1748758