Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop relapse and repopulate the tumor following drug withdrawal. Using a cancer cell line with an engineered suicide switch to kill proliferating cel...

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Vydáno v:	Cell reports. Medicine Ročník 5; číslo 3; s. 101471
Hlavní autoři:	Chen, Mengnuo, Mainardi, Sara, Lieftink, Cor, Velds, Arno, de Rink, Iris, Yang, Chen, Kuiken, Hendrik J., Morris, Ben, Edwards, Finn, Jochems, Fleur, van Tellingen, Olaf, Boeije, Manon, Proost, Natalie, Jansen, Robin A., Qin, Shifan, Jin, Haojie, Koen van der Mijn, J.C., Schepers, Arnout, Venkatesan, Subramanian, Qin, Wenxin, Beijersbergen, Roderick L., Wang, Liqin, Bernards, René
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 19.03.2024 Elsevier
Témata:	Advanced Basic Science Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics
ISSN:	2666-3791, 2666-3791
On-line přístup:	Získat plný text
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