Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop relapse and repopulate the tumor following drug withdrawal. Using a cancer cell line with an engineered suicide switch to kill proliferating cel...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell reports. Medicine Jg. 5; H. 3; S. 101471
Hauptverfasser:	Chen, Mengnuo, Mainardi, Sara, Lieftink, Cor, Velds, Arno, de Rink, Iris, Yang, Chen, Kuiken, Hendrik J., Morris, Ben, Edwards, Finn, Jochems, Fleur, van Tellingen, Olaf, Boeije, Manon, Proost, Natalie, Jansen, Robin A., Qin, Shifan, Jin, Haojie, Koen van der Mijn, J.C., Schepers, Arnout, Venkatesan, Subramanian, Qin, Wenxin, Beijersbergen, Roderick L., Wang, Liqin, Bernards, René
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 19.03.2024 Elsevier
Schlagworte:	Advanced Basic Science Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics
ISSN:	2666-3791, 2666-3791
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!