Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop relapse and repopulate the tumor following drug withdrawal. Using a cancer cell line with an engineered suicide switch to kill proliferating cel...

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Bibliographic Details

Published in:	Cell reports. Medicine Vol. 5; no. 3; p. 101471
Main Authors:	Chen, Mengnuo, Mainardi, Sara, Lieftink, Cor, Velds, Arno, de Rink, Iris, Yang, Chen, Kuiken, Hendrik J., Morris, Ben, Edwards, Finn, Jochems, Fleur, van Tellingen, Olaf, Boeije, Manon, Proost, Natalie, Jansen, Robin A., Qin, Shifan, Jin, Haojie, Koen van der Mijn, J.C., Schepers, Arnout, Venkatesan, Subramanian, Qin, Wenxin, Beijersbergen, Roderick L., Wang, Liqin, Bernards, René
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 19.03.2024 Elsevier
Subjects:	Advanced Basic Science Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics
ISSN:	2666-3791, 2666-3791
Online Access:	Get full text
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