Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma

Sphingosine-1-phosphate receptor (S1PR) signaling regulates diverse pathophysiological processes in the central nervous system. The role of S1PR signaling in neurodegenerative conditions is still largely unidentified. Siponimod is a specific modulator of S1P1 and S1P5 receptors, an immunosuppressant...

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Published in:	Neural regeneration research Vol. 18; no. 4; pp. 840 - 848
Main Authors:	Basavarajappa, Devaraj, Gupta, Vivek, Chitranshi, Nitin, Wall, Roshana, Rajput, Rashi, Pushpitha, Kanishka, Sharma, Samridhi, Mirzaei, Mehdi, Klistorner, Alexander, Graham, Stuart
Format:	Journal Article
Language:	English
Published:	Mumbai Wolters Kluwer India Pvt. Ltd 01.04.2023 Medknow Publications & Media Pvt. Ltd Department of Clinical Medicine,Faculty of Medicine,Health and Human Sciences,Macquarie University,North Ryde,Sydney,NSW,Australia Wolters Kluwer - Medknow Wolters Kluwer Medknow Publications
Subjects:	Glaucoma glaucoma; intraocular pressure; neurodegeneration; neuroprotection; optic nerve injury; retinal ganglion cells; siponimod; sphingosine-1-phosphate Nervous system Optic nerve Retina intraocular pressure glaucoma neuroprotection neurodegeneration optic nerve injury retinal ganglion cells sphingosine-1-phosphate siponimod
ISSN:	1673-5374, 1876-7958
Online Access:	Get full text
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