Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-inducible expression of a battery of genes encoding key components of the glutathione-based and thioredoxin-based antioxidant systems, as well as aldo-keto reductase, glutathione S-transferase, and NAD(P)H:quinone...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 88; no. Pt B; pp. 108 - 146
Main Authors:	Tebay, Lauren E., Robertson, Holly, Durant, Stephen T., Vitale, Steven R., Penning, Trevor M., Dinkova-Kostova, Albena T., Hayes, John D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2015
Subjects:	aldo-keto reductase (AKR) Animals Carcinogenesis - metabolism Free radicals Glutathione GSK-3 Humans Inflammation Keap1 Lipid metabolism NF-E2-Related Factor 2 - metabolism Nrf2 Nutrient supply Oxidation-Reduction Oxidative Stress - physiology Reactive oxygen species Signal Transduction - physiology Thioredoxin β-TrCP Reactive oxygen species Free radicals Nrf2 aldo-keto reductase (AKR) Keap1 GSK-3 Inflammation Nutrient supply Lipid metabolism β-TrCP Thioredoxin Glutathione
ISSN:	0891-5849, 1873-4596
Online Access:	Get full text
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