Alcohol Consumption as a Risk Factor for Dementia and Cognitive Decline: Meta-Analysis of Prospective Studies

The relationships between alcohol consumption and dementia and cognitive decline were investigated in a systematic review including meta-analyses of 15 prospective studies. Follow-ups ranged from 2 to 8 years. Meta-analyses were conducted on samples including 14,646 participants evaluated for Alzhei...

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Veröffentlicht in:	The American journal of geriatric psychiatry Jg. 17; H. 7; S. 542 - 555
Hauptverfasser:	Anstey, Kaarin J., Mack, Holly A., Cherbuin, Nicolas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Inc 01.07.2009 Elsevier Limited
Schlagworte:	Aged Aged, 80 and over Alcohol Amnestic Disorder - diagnosis Alcohol Amnestic Disorder - epidemiology Alcohol Amnestic Disorder - etiology Alcohol Amnestic Disorder - psychology alcohol drinking Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol Drinking - psychology Alcohol use Alcoholism - complications Alcoholism - epidemiology Alcoholism - psychology Alzheimer disease Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - etiology Alzheimer Disease - psychology Alzheimer's disease Cognition Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - psychology Cognitive impairment Cohort analysis Comorbidity Consumption Cross-Sectional Studies Dementia Dementia - diagnosis Dementia - epidemiology Dementia - etiology Dementia - psychology Dementia, Vascular - diagnosis Dementia, Vascular - epidemiology Dementia, Vascular - etiology Dementia, Vascular - psychology Drinking behavior epidemiology Follow-Up Studies Humans Internal Medicine Life Longitudinal studies Meta-analysis mild cognitive impairment Prospective studies Risk Risk factors Sampling Selection effects Systematic review vascular dementia epidemiology mild cognitive impairment systematic review Alzheimer disease vascular dementia alcohol drinking
ISSN:	1064-7481, 1545-7214
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Zusammenfassung:	The relationships between alcohol consumption and dementia and cognitive decline were investigated in a systematic review including meta-analyses of 15 prospective studies. Follow-ups ranged from 2 to 8 years. Meta-analyses were conducted on samples including 14,646 participants evaluated for Alzheimer disease (AD), 10,225 participants evaluated for vascular dementia (VaD), and 11,875 followed for any type of dementia (Any dementia). The pooled relative risks (RRs) of AD, VaD, and Any dementia for light to moderate drinkers compared with nondrinkers were 0.72 (95% CI = 0.61–0.86), 0.75 (95% CI = 0.57–0.98), and 0.74 (95% CI = 0.61–0.91), respectively. When the more generally classified “drinkers,” were compared with “nondrinkers,” they had a reduced risk of AD (RR = 0.66, 95% CI = 0.47–0.94) and Any dementia (RR = 0.53, 95% CI = 0.53–0.82) but not cognitive decline. There were not enough data to examine VaD risk among “drinkers.” Those classified as heavy drinkers did not have an increased risk of Any dementia compared with nondrinkers, but this may reflect sampling bias. Our results suggest that alcohol drinkers in late life have reduced risk of dementia. It is unclear whether this reflects selection effects in cohort studies commencing in late life, a protective effect of alcohol consumption throughout adulthood, or a specific benefit of alcohol in late life.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	1064-7481 1545-7214
DOI:	10.1097/JGP.0b013e3181a2fd07