Synthesis and Antineoplastic Activity of a Dimer, Spiroindolinone Pyrrolidinecarboxamide

The mutation or function loss of tumour suppressor p53 plays an important role in abnormal cell proliferation and cancer generation. Murine Double Minute 2 (MDM2) is one of the key negative regulators of p53. p53 reactivation by inhibiting MDM2–p53 interaction represents a promising therapeutic opti...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 28; no. 9; p. 3912
Main Authors:	Cui, Jingyi, Wang, Yujie, Li, Xiaoxin, Xiao, Fei, Ren, Hongjun, Wu, Meng
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 05.05.2023 MDPI
Subjects:	Animals Antineoplastic Agents - pharmacology Apoptosis Cancer cancer treatment Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell Proliferation dimer spiroindolinone pyrrolidinecarboxamide Genes Genetic aspects Health aspects Humans Hydrochloric acid Influence MDM2 inhibitor Mice Mutation p53 activation Prevention Prostate cancer Proteins Proteolysis Proto-Oncogene Proteins c-mdm2 - metabolism Regulatory approval Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis China cancer treatment dimer spiroindolinone pyrrolidinecarboxamide p53 activation MDM2 inhibitor
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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